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Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide

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Science Translational Medicine  12 May 2021:
Vol. 13, Issue 593, eabb3768
DOI: 10.1126/scitranslmed.abb3768

Article Information

vol. 13 no. 593

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 14, 2020
  • Accepted for publication April 20, 2021
  • .

Author Information

  1. Brock J. Sishc1,
  2. Lianghao Ding1,
  3. Taek-Keun Nam1,,
  4. Collin D. Heer2,
  5. Samuel N. Rodman2,
  6. Joshua D. Schoenfeld2,
  7. Melissa A. Fath2,
  8. Debabrata Saha1,
  9. Casey F. Pulliam2,
  10. Britta Langen1,
  11. Robert A. Beardsley3,
  12. Dennis P. Riley3,
  13. Jeffery L. Keene3,
  14. Douglas R. Spitz3,* and
  15. Michael D. Story1,*
  1. 1Division of Molecular Radiation Biology, Department of Radiation Oncology, and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  2. 2Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA.
  3. 3Galera Therapeutics Inc., 2 West Liberty Blvd., Suite 110, Malvern, PA 19355, USA.
  1. *Corresponding author. Email: michael.story{at}utsouthwestern.edu (M.D.S.); douglas-spitz{at}uiowa.edu (D.R.S.)
  • Present address: Department of Radiation Oncology, Chonnam National University Hwasun Hospital, Hwasun-eup, Hwasun-gun, Jeollanam-do 58128, Korea.

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