12 May 2021
Vol 13, Issue 593

About The Cover

Cover image expansion

ONLINE COVER Destructive CD4+ T Cells. This image shows a hematoxylin and eosin-stained section of an inflamed mouse thyroid following immunization with thyroglobulin and treatment with programmed cell death protein 1 (PD-1) antibody. Immune-related adverse events (irAEs) sometimes occur in patients treated with PD-1 antibody or other immune checkpoint blockade therapies. One type of irAE is destructive thyroiditis, where immune cells kill healthy thyroid cells. In this study, Yasuda et al. developed a mouse model of destructive thyroiditis and showed that a population of cytotoxic CD4+ T cells are essential for thyroid damage. These findings suggest that CD4+ T cells should be investigated as mediators of irAEs in humans treated with PD-1 antibody. [CREDIT: YASUDA ET AL./SCIENCE TRANSLATIONAL MEDICINE]