Research ArticlePregnancy

Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset

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Science Translational Medicine  05 May 2021:
Vol. 13, Issue 592, eabd9898
DOI: 10.1126/scitranslmed.abd9898

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Toward better prediction of labor

Current methods to predict spontaneous labor are fairly inaccurate. To provide better estimates and biomarkers of labor onset, the biological processes that lead up to labor need to be better understood. Stelzer et al. performed metabolome, proteome, and immunome studies on blood samples from 63 women in the 100 days before delivery. They identified a surge in IL-1R4 and steroid hormones in the weeks before delivery, which was coordinated with a switch from immune activation to regulation of inflammatory responses. A model was then constructed to predict time to labor independent of gestational age. These results may be helpful for development of more accurate methods to predict labor.

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