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SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma

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Science Translational Medicine  28 Apr 2021:
Vol. 13, Issue 591, eabe7378
DOI: 10.1126/scitranslmed.abe7378

Article Information

vol. 13 no. 591

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 10, 2020
  • Resubmitted December 26, 2020
  • Accepted for publication February 17, 2021
  • .

Author Information

  1. Joseph H. Choe1,,
  2. Payal B. Watchmaker2,,
  3. Milos S. Simic1,,
  4. Ryan D. Gilbert2,
  5. Aileen W. Li1,
  6. Nira A. Krasnow1,
  7. Kira M. Downey2,
  8. Wei Yu1,
  9. Diego A. Carrera2,
  10. Anna Celli3,
  11. Juhyun Cho1,
  12. Jessica D. Briones1,
  13. Jason M. Duecker1,
  14. Yitzhar E. Goretsky2,
  15. Ruth Dannenfelser4,5,
  16. Lia Cardarelli6,7,
  17. Olga Troyanskaya4,5,
  18. Sachdev S. Sidhu6,7,
  19. Kole T. Roybal1,8,9,10,11,*,
  20. Hideho Okada2,8,11,* and
  21. Wendell A. Lim1,11,12,*
  1. 1Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
  2. 2Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA.
  3. 3Department of Veterans’ Affairs Medical Center, University of California, San Francisco, San Francisco, CA 94158, USA.
  4. 4Department of Computer Science, Princeton University, Princeton, NJ 08540, USA.
  5. 5Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA.
  6. 6Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  7. 7Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
  8. 8Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94158, USA.
  9. 9Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA.
  10. 10Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
  11. 11Helen Diller Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
  12. 12Howard Hughes Medical Institute, San Francisco, CA 94158, USA.
  1. *Corresponding author. Email: kole.roybal{at}ucsf.edu (K.T.R.); hideho.okada{at}ucsf.edu (H.O.); wendell.lim{at}ucsf.edu (W.A.L.)
  • These authors contributed equally to this work.

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