Research ArticleMetabolism

SHP2 drives inflammation-triggered insulin resistance by reshaping tissue macrophage populations

See allHide authors and affiliations

Science Translational Medicine  28 Apr 2021:
Vol. 13, Issue 591, eabe2587
DOI: 10.1126/scitranslmed.abe2587

Article Information

vol. 13 no. 591

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 17, 2020
  • Accepted for publication April 5, 2021
  • .

Author Information

  1. Romain Paccoud1,,
  2. Céline Saint-Laurent1,2,
  3. Enzo Piccolo1,2,
  4. Mylène Tajan1,2,
  5. Alizée Dortignac1,
  6. Ophélie Pereira1,2,
  7. Sophie Le Gonidec1,2,
  8. Inès Baba3,
  9. Adélaïde Gélineau3,
  10. Haoussa Askia3,
  11. Maxime Branchereau1,
  12. Julie Charpentier1,
  13. Jean Personnaz1,
  14. Sophie Branka1,
  15. Johanna Auriau1,
  16. Simon Deleruyelle1,
  17. Mickaël Canouil4,
  18. Nicolas Beton5,
  19. Jean-Pierre Salles5,
  20. Maithé Tauber5,
  21. Jacques Weill4,
  22. Philippe Froguel4,6,
  23. Benjamin G. Neel7,
  24. Toshiyuki Araki7,
  25. Christophe Heymes1,
  26. Rémy Burcelin1,
  27. Isabelle Castan1,2,
  28. Philippe Valet1,2,
  29. Cédric Dray1,2,
  30. Emmanuel L. Gautier3,
  31. Thomas Edouard2,5,
  32. Jean-Philippe Pradère1,2, and
  33. Armelle Yart1,2,*,
  1. 1Institut des Maladies Métaboliques et Cardiovasculaires, INSERM UMR 1048, Université Paul Sabatier, Université de Toulouse, Toulouse F-31432, France.
  2. 2RESTORE, INSERM UMR1301, CNRS UMR5070, Université Paul Sabatier, Université de Toulouse, Toulouse F-31100, France.
  3. 3INSERM UMR-S 1166, Sorbonne Université, Hôpital de la Pitié-Salpêtrière, Paris F-75013, France.
  4. 4INSERM UMR 1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille University Hospital, Lille F-59000, France.
  5. 5Endocrine, Bone Diseases, and Genetics Unit, Children’s Hospital, Toulouse University Hospital, Toulouse France and Centre de Physiopathologie Toulouse-Purpan, INSERM UMR 1043, Université Paul Sabatier, Université de Toulouse, Toulouse F-31024, France.
  6. 6Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.
  7. 7Laura and Isaac Perlmutter Cancer Center, NYU-Langone Medical Center, NY 10016, USA.
  1. *Corresponding author. Email: armelle.yart{at}inserm.fr
  • Present address: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

  • These authors jointly directed this work.

Altmetric

Article usage

Article usage: April 2021 to May 2021

AbstractFullPdf
Apr 20212711308204
May 20212638161107

Stay Connected to Science Translational Medicine