Research ArticleParkinson’s Disease

Robot-induced hallucinations in Parkinson’s disease depend on altered sensorimotor processing in fronto-temporal network

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Science Translational Medicine  28 Apr 2021:
Vol. 13, Issue 591, eabc8362
DOI: 10.1126/scitranslmed.abc8362

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Grasping hallucinations in PD

Nearly half of the patients with Parkinson’s disease (PD) experience hallucinations, and recent studies have shown that hallucinations are associated with negative cognitive outcome and higher mortality. Now, Bernasconi et al. used a robotic method to induce hallucinations in patients with PD to study the mechanisms behind this symptom. The authors identified a subgroup of patients with increased sensitivity to hallucinations and used magnetic resonance to show that frontotemporal connectivity, associated with hallucinations in healthy participants, was disrupted in patients with PD suffering from hallucinations. The results might improve diagnosis of hallucinations in patients with PD and facilitate the development of targeted therapies.

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