Research ArticleAcute Lung Injury

Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3

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Science Translational Medicine  28 Apr 2021:
Vol. 13, Issue 591, eabc2499
DOI: 10.1126/scitranslmed.abc2499

Article Information

vol. 13 no. 591

PubMed: 
Print ISSN: 
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History: 
  • Received for publication April 14, 2020
  • Resubmitted September 30, 2020
  • Accepted for publication January 4, 2021
  • .

Author Information

  1. Qianying Yuan1,2,,
  2. Abdul Basit1,2,,
  3. Wenhua Liang3,,
  4. Rihao Qu4,5,
  5. Yi Luan1,2,
  6. Chunguang Ren1,2,
  7. Ao Li1,2,
  8. Xin Xu3,
  9. Xiaoqing Liu3,
  10. Chun Yang3,
  11. Andrew Kuo1,2,
  12. Richard Pierce1,
  13. Longbo Zhang6,
  14. Benjamin Turk2,
  15. Xin Hu7,
  16. Fangyong Li7,
  17. Weixue Cui3,
  18. Run Li3,
  19. Danxia Huang3,
  20. Lili Mo3,
  21. William C. Sessa1,2,
  22. Patty J. Lee8,
  23. Yuval Kluger5,
  24. Bing Su9,*,
  25. Wenwen Tang1,2,*,
  26. Jianxing He3,* and
  27. Dianqing Wu1,2,*
  1. 1Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA.
  2. 2Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
  3. 3Department of Thoracic Surgery/Oncology, First Affiliated Hospital of Guangzhou Medical University, China State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou 510120, China.
  4. 4Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
  5. 5Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.
  6. 6Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.
  7. 7Department of Biostatistics, Yale University School of Medicine, New Haven, CT 06520, USA.
  8. 8Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
  9. 9Shanghai Institute of Immunology, Shanghai Jiaotong University, Shanghai 200025, China.
  1. *Corresponding author. Email: dan.wu{at}yale.edu (D.W.); drjianxing.he{at}gmail.com (J.H.); wenwen.tang{at}yale.edu (W.T.); bingsu{at}sjtu.edu.cn (B.S.)
  • These authors contributed equally to this work.

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