Research ArticleCORONAVIRUS

T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals

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Science Translational Medicine  21 Apr 2021:
Vol. 13, Issue 590, eabf7517
DOI: 10.1126/scitranslmed.abf7517

T cells keep it up

A major focus of investigation for researches studying severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) is how long immunological memory persists after infection. In this study, Bilich et al. specifically explored the kinetics of SARS-CoV-2–specific T cell responses in two cohorts of patients up to 6 months after infection. The authors found that, whereas antibody responses wane, T cell responses to SARS-CoV-2 antigens remain consistent or increase over time. These findings are supported by other studies and suggest that vaccines that elicit T cell responses may be essential for providing long-term protection against SARS-CoV-2 infection.

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