Research ArticleStroke

Patient-derived glial enriched progenitors repair functional deficits due to white matter stroke and vascular dementia in rodents

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Science Translational Medicine  21 Apr 2021:
Vol. 13, Issue 590, eaaz6747
DOI: 10.1126/scitranslmed.aaz6747

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Astro-therapy for stroke

Astrocytes, axons, and myelin are subjected to major damage during subcortical white matter stroke (WMS), a debilitating disorder leading to cognitive and motor impairments. Previous studies have shown that immature astrocyte transplantation could promote remyelination in rodent models. Now, Llorente et al. used a model of WMS in mice to demonstrate that transplantation of glial enriched progenitor cells differentiated from human-induced pluripotent stem cells (hiPSC-GEPs) shortly after stroke matured into a mature astrocyte phenotype and had therapeutic effect on axonal damage, demyelination, and cognitive impairments more effectively than hiPSC-derived neuronal precursor cells. The results suggest that astrocyte precursors have therapeutic potential in stroke.

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