Research ArticleLung Disease

Fetal lung underdevelopment is rescued by administration of amniotic fluid stem cell extracellular vesicles in rodents

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Science Translational Medicine  21 Apr 2021:
Vol. 13, Issue 590, eaax5941
DOI: 10.1126/scitranslmed.aax5941

Article Information

vol. 13 no. 590

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication April 8, 2019
  • Resubmitted March 4, 2020
  • Accepted for publication December 28, 2020
  • .

Author Information

  1. Lina Antounians1,2,
  2. Vincenzo D. Catania1,2,
  3. Louise Montalva1,2,
  4. Benjamin D. Liu1,2,
  5. Huayun Hou3,4,
  6. Cadia Chan3,4,
  7. Andreea C. Matei1,2,
  8. Areti Tzanetakis1,2,
  9. Bo Li2,5,
  10. Rebeca L. Figueira6,
  11. Karina M. da Costa6,
  12. Amy P. Wong1,
  13. Robert Mitchell7,
  14. Anna L. David8,9,
  15. Ketan Patel7,10,
  16. Paolo De Coppi11,12,
  17. Lourenço Sbragia6,
  18. Michael D. Wilson3,4,
  19. Janet Rossant1,4 and
  20. Augusto Zani1,2,13,*
  1. 1Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, M5G 0A4, Canada.
  2. 2Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.
  3. 3Genetics and Genome Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, M5G 0A4, Canada.
  4. 4Department of Molecular Genetics, University of Toronto, Toronto, M5S 1A8, Canada.
  5. 5Translational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, M5G 0A4, Canada.
  6. 6Laboratory of Experimental Fetal and Neonatal Surgery, Division of Pediatric Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paolo, 14049-900, Brazil.
  7. 7School of Biological Sciences, University of Reading, Reading RG6 6AS, UK.
  8. 8Institute for Women’s Health, University College London, London WC1E 6HU, UK.
  9. 9NIHR University College London Hospitals Biomedical Research Centre, London W1T 7HA, UK.
  10. 10FRIAS Freiburg Institute for Advanced Studies, University of Freiburg, Freiburg 79104, Germany.
  11. 11Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London, London WC1N 1EH, UK.
  12. 12NIHR Biomedical Research Centre and Specialist Neonatal and Paediatric Unit, Great Ormond Street Hospital, London WC1N 1EH, UK.
  13. 13Department of Surgery, University of Toronto, Toronto, M5T 1P5, Canada.
  1. *Corresponding author. Email: augusto.zani{at}sickkids.ca

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