Research ArticleLung Disease

Fetal lung underdevelopment is rescued by administration of amniotic fluid stem cell extracellular vesicles in rodents

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Science Translational Medicine  21 Apr 2021:
Vol. 13, Issue 590, eaax5941
DOI: 10.1126/scitranslmed.aax5941

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Promoting lung development with EVs

Pulmonary hypoplasia is a congenital malformation due to incomplete development of the lungs. Currently, there are no therapies that effectively promote lung development. Here, Antounians et al. used in vivo and ex vivo rodent models and a lung injury model in human alveolar epithelial cells to demonstrate that the intratracheal administration of amniotic fluid stem cell–derived extracellular vesicles (AFSC-EVs) promoted lung regeneration by releasing their RNA content. Early administration of AFSC-EVs in fetuses with pulmonary hypoplasia could be an effective therapy for promoting lung development and reducing other secondary fetal abnormalities associated with incomplete lung development.

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