21 April 2021
Vol 13, Issue 590

About The Cover

Cover image expansion

ONLINE COVER Axons in Anorexia. The image shows Mc3r mRNA (green) in Agrp (red)- and Pomc (blue)-expressing AgRP (Agouti-related protein) neurons in the arcuate nucleus of the mouse hypothalamus. Sweeney et al. showed that AgRP neurons, known to regulate feeding behavior, can be bidirectionally controlled by deletion of Mc3r or pharmacological manipulation of melanocortin-3 receptor (MC3R). MC3R-specific agonists increased feeding in male and female mice, including models of anorexia, by modulating AgRP neurons. Conversely, inhibition of MC3R suppressed food intake. These results suggest that MC3R may constitute a therapeutic target for anorexia nervosa. [CREDIT: SWEENEY ET AL./SCIENCE TRANSLATIONAL MEDICINE]