07 April 2021
Vol 13, Issue 588

About The Cover

Cover image expansion

ONLINE COVER Taking Diabetes Down a Notch. The image shows a cross-section of pancreas from a healthy mouse exposed to anti-serpinB13 monoclonal antibodies during embryonic development. Kryvalap et al. found that antibody-mediated inhibition of serpinB13 decreased Notch signaling and increased pancreatic progenitor cell formation in mice, resulting in enhanced β cell mass as indicated by increased staining for insulin (pink) and resistance to streptozocin-induced diabetes later in adulthood. Presence of anti-serpinB13 autoantibodies was associated with delayed type 1 diabetes in children, hinting at the prophylactic potential of targeting serpinB13 in humans. [CREDIT: KRYVALAP ET AL./SCIENCE TRANSLATIONAL MEDICINE]