Research ArticleDiagnostics

Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR

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Science Translational Medicine  07 Apr 2021:
Vol. 13, Issue 588, eabd9696
DOI: 10.1126/scitranslmed.abd9696

Article Information

vol. 13 no. 588

Print ISSN: 
Online ISSN: 
  • Received for publication July 23, 2020
  • Accepted for publication March 12, 2021
  • .

Author Information

  1. Cassio M. Fontes1,,
  2. Barbara D. Lipes2,,
  3. Jason Liu1,,
  4. Krystle N. Agans3,4,
  5. Aiwei Yan2,
  6. Patricia Shi2,
  7. Daniela F. Cruz1,
  8. Garrett Kelly1,
  9. Kelli M. Luginbuhl1,
  10. Daniel Y. Joh1,
  11. Stephanie L. Foster3,4,
  12. Jacob Heggestad1,
  13. Angus Hucknall1,
  14. Maiken H. Mikkelsen5,
  15. Carl F. Pieper6,
  16. Roarke W. Horstmeyer1,
  17. Thomas W. Geisbert3,4,
  18. Michael D. Gunn2,* and
  19. Ashutosh Chilkoti1,*
  1. 1Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
  2. 2Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  3. 3Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
  4. 4Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX 77550, USA.
  5. 5Department of Electrical and Computer Engineering, Duke University, Durham, NC 27708, USA.
  6. 6Departments of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USA.
  1. *Corresponding author. Email: michael.gunn{at} (M.D.G.); ashutosh.chilkoti{at} (A.C.)
  • These authors contributed equally to this work.


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