Research ArticleStroke

Plasmin-resistant PSD-95 inhibitors resolve effect-modifying drug-drug interactions between alteplase and nerinetide in acute stroke

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Science Translational Medicine  07 Apr 2021:
Vol. 13, Issue 588, eabb1498
DOI: 10.1126/scitranslmed.abb1498

Article Information

vol. 13 no. 588

Print ISSN: 
Online ISSN: 
  • Received for publication February 3, 2020
  • Resubmitted October 12, 2020
  • Accepted for publication January 14, 2021
  • .

Author Information

  1. Diana Mayor-Nunez1,2,3,
  2. Zhanxin Ji1,
  3. Xiujun Sun1,
  4. Lucy Teves3,
  5. J. David Garman1 and
  6. Michael Tymianski1,2,3,4,*
  1. 1NoNO Inc., Toronto, Ontario M5V 1E7, Canada.
  2. 2Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  3. 3Krembil Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada.
  4. 4Department of Surgery, University of Toronto, Toronto, Ontario M5T 1P5, Canada.
  1. *Corresponding author. Email: mtymianski{at}


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Article usage: April 2021 to April 2021

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