Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

Peiling Luan; Davide D’Amico; Pénélope A. Andreux; Pirkka-Pekka Laurila; Martin Wohlwend; Hao Li; Tanes Imamura de Lima; Nicolas Place; Chris Rinsch; Nadège Zanou; Johan Auwerx

doi:10.1126/scitranslmed.abb0319

Research ArticleMuscular Dystrophy

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

View ORCID ProfilePeiling Luan¹,†,
View ORCID ProfileDavide D’Amico¹,²,†,
View ORCID ProfilePénélope A. Andreux²,
Pirkka-Pekka Laurila ¹,
View ORCID ProfileMartin Wohlwend¹,
View ORCID ProfileHao Li¹,
View ORCID ProfileTanes Imamura de Lima¹,
View ORCID ProfileNicolas Place³,
Chris Rinsch²,
Nadège Zanou³ and
View ORCID ProfileJohan Auwerx ¹,*

¹Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
²Amazentis SA, Ecole Polytechnique Fédérale de Lausanne (EPFL) Innovation Park, 1015 Lausanne, Switzerland.
³Institute of Sport Sciences, Quartier UNIL-Centre, Faculty of Biology-Medicine, University of Lausanne, Bâtiment Synathlon, 1015 Lausanne, Switzerland.

↵*Corresponding author. Email: admin.auwerx{at}epfl.ch

↵† These authors contributed equally to this work.

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Science Translational Medicine 07 Apr 2021:
Vol. 13, Issue 588, eabb0319
DOI: 10.1126/scitranslmed.abb0319

Peiling Luan

1Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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ORCID record for Peiling Luan

Davide D’Amico

1Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

2Amazentis SA, Ecole Polytechnique Fédérale de Lausanne (EPFL) Innovation Park, 1015 Lausanne, Switzerland.

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Pénélope A. Andreux

2Amazentis SA, Ecole Polytechnique Fédérale de Lausanne (EPFL) Innovation Park, 1015 Lausanne, Switzerland.

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ORCID record for Pénélope A. Andreux

Pirkka-Pekka Laurila

1Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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Martin Wohlwend

1Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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Hao Li

1Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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Tanes Imamura de Lima

1Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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Nicolas Place

3Institute of Sport Sciences, Quartier UNIL-Centre, Faculty of Biology-Medicine, University of Lausanne, Bâtiment Synathlon, 1015 Lausanne, Switzerland.

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Chris Rinsch

2Amazentis SA, Ecole Polytechnique Fédérale de Lausanne (EPFL) Innovation Park, 1015 Lausanne, Switzerland.

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Nadège Zanou

3Institute of Sport Sciences, Quartier UNIL-Centre, Faculty of Biology-Medicine, University of Lausanne, Bâtiment Synathlon, 1015 Lausanne, Switzerland.

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Johan Auwerx

1Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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ORCID record for Johan Auwerx
For correspondence: admin.auwerx@epfl.ch

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Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

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