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Research ArticleMuscular Dystrophy
Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy
- View ORCID ProfilePeiling Luan1,†,
- View ORCID ProfileDavide D’Amico1,2,†,
- View ORCID ProfilePénélope A. Andreux2,
- Pirkka-Pekka Laurila1,
- View ORCID ProfileMartin Wohlwend1,
- View ORCID ProfileHao Li1,
- View ORCID ProfileTanes Imamura de Lima1,
- View ORCID ProfileNicolas Place3,
- Chris Rinsch2,
- Nadège Zanou3 and
- View ORCID ProfileJohan Auwerx1,*
- 1Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
- 2Amazentis SA, Ecole Polytechnique Fédérale de Lausanne (EPFL) Innovation Park, 1015 Lausanne, Switzerland.
- 3Institute of Sport Sciences, Quartier UNIL-Centre, Faculty of Biology-Medicine, University of Lausanne, Bâtiment Synathlon, 1015 Lausanne, Switzerland.
- ↵*Corresponding author. Email: admin.auwerx{at}epfl.ch
↵† These authors contributed equally to this work.
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Science Translational Medicine 07 Apr 2021:
Vol. 13, Issue 588, eabb0319
DOI: 10.1126/scitranslmed.abb0319
Vol. 13, Issue 588, eabb0319
DOI: 10.1126/scitranslmed.abb0319
Peiling Luan
1Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Davide D’Amico
1Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
2Amazentis SA, Ecole Polytechnique Fédérale de Lausanne (EPFL) Innovation Park, 1015 Lausanne, Switzerland.
Pénélope A. Andreux
2Amazentis SA, Ecole Polytechnique Fédérale de Lausanne (EPFL) Innovation Park, 1015 Lausanne, Switzerland.
Pirkka-Pekka Laurila
1Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Martin Wohlwend
1Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Hao Li
1Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Tanes Imamura de Lima
1Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Nicolas Place
3Institute of Sport Sciences, Quartier UNIL-Centre, Faculty of Biology-Medicine, University of Lausanne, Bâtiment Synathlon, 1015 Lausanne, Switzerland.
Chris Rinsch
2Amazentis SA, Ecole Polytechnique Fédérale de Lausanne (EPFL) Innovation Park, 1015 Lausanne, Switzerland.
Nadège Zanou
3Institute of Sport Sciences, Quartier UNIL-Centre, Faculty of Biology-Medicine, University of Lausanne, Bâtiment Synathlon, 1015 Lausanne, Switzerland.
Johan Auwerx
1Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
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