Contents

Research Articles

• SerpinB13 antibodies promote β cell development and resistance to type 1 diabetes

  By Yury Kryvalap, Matthew L. Jiang, Nadzeya Kryvalap, Cole Hendrickson, Jan Czyzyk

  Science Translational Medicine07 Apr 2021 Full AccessRestricted Access

  Antibody binding to protease inhibitor serpinB13 promotes proteolytic breakdown of Notch1 and generation of pancreatic endocrine cells.

  • Editor's Summary
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• A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma

  By Weiqin Yang, Yu Feng, Jingying Zhou, Otto Ka-Wing Cheung, Jianquan Cao, Jing Wang, Wenshu Tang, Yalin Tu, Liangliang Xu, Feng Wu, Zhiwu Tan, Hanyong Sun, Yuan Tian, John Wong, Paul Bo-San Lai, Stephen Lam Chan, Anthony Wing-Hung Chan, Patrick Boon-Ooi Tan, Zhiwei Chen, Joseph Jao-Yiu Sung, Kevin Yuk-Lap Yip, Ka-Fai To, Alfred Sze-Lok Cheng

  Science Translational Medicine07 Apr 2021 Full AccessRestricted Access

  HDAC8 inhibition elicits durable responses to immune checkpoint blockade by improving adaptive immune responses through enhancer reprogramming.

  • Editor's Summary
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• Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR

  By Cassio M. Fontes, Barbara D. Lipes, Jason Liu, Krystle N. Agans, Aiwei Yan, Patricia Shi, Daniela F. Cruz, Garrett Kelly, Kelli M. Luginbuhl, Daniel Y. Joh, Stephanie L. Foster, Jacob Heggestad, Angus Hucknall, Maiken H. Mikkelsen, Carl F. Pieper, Roarke W. Horstmeyer, Thomas W. Geisbert, Michael D. Gunn, Ashutosh Chilkoti

  Science Translational Medicine07 Apr 2021 Full AccessRestricted Access

  An immunoassay that targets the nonstructural secreted glycoprotein decoy antigen of Ebola virus detects infection earlier than PCR.

  • Editor's Summary
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• Widespread and sustained target engagement in Huntington’s disease minipigs upon intrastriatal microRNA-based gene therapy

  By Astrid Vallès, Melvin M. Evers, Anouk Stam, Marina Sogorb-Gonzalez, Cynthia Brouwers, Carlos Vendrell-Tornero, Seyda Acar-Broekmans, Lieke Paerels, Jiri Klima, Bozena Bohuslavova, Roberta Pintauro, Valentina Fodale, Alberto Bresciani, Roman Liscak, Dusan Urgosik, Zdenek Starek, Michal Crha, Bas Blits, Harald Petry, Zdenka Ellederova, Jan Motlik, Sander van Deventer, Pavlina Konstantinova

  Science Translational Medicine07 Apr 2021 Full AccessRestricted Access

  Striatal delivery of microRNA-gene therapy results in widespread brain huntingtin protein lowering in Huntington’s disease minipigs up to 1 year.

  • Editor's Summary
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• Plasmin-resistant PSD-95 inhibitors resolve effect-modifying drug-drug interactions between alteplase and nerinetide in acute stroke

  By Diana Mayor-Nunez, Zhanxin Ji, Xiujun Sun, Lucy Teves, J. David Garman, Michael Tymianski

  Science Translational Medicine07 Apr 2021 Full AccessRestricted Access

  The plasma stability and neuroprotective effectiveness of nerinetide are enhanced by partially substituting l- to d-amino acids.

  • Editor's Summary
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• Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

  By Peiling Luan, Davide D’Amico, Pénélope A. Andreux, Pirkka-Pekka Laurila, Martin Wohlwend, Hao Li, Tanes Imamura de Lima, Nicolas Place, Chris Rinsch, Nadège Zanou, Johan Auwerx

  Science Translational Medicine07 Apr 2021 Full AccessRestricted Access

  The mitophagy inducer urolithin A reverts muscular dystrophies.

  • Editor's Summary
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  • Supplementary Materials