Contents
07 April 2021
Vol 13, Issue 588
Vol 13, Issue 588
Research Articles
- SerpinB13 antibodies promote β cell development and resistance to type 1 diabetes
Antibody binding to protease inhibitor serpinB13 promotes proteolytic breakdown of Notch1 and generation of pancreatic endocrine cells.
- A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma
HDAC8 inhibition elicits durable responses to immune checkpoint blockade by improving adaptive immune responses through enhancer reprogramming.
- Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR
An immunoassay that targets the nonstructural secreted glycoprotein decoy antigen of Ebola virus detects infection earlier than PCR.
- Widespread and sustained target engagement in Huntington’s disease minipigs upon intrastriatal microRNA-based gene therapy
Striatal delivery of microRNA-gene therapy results in widespread brain huntingtin protein lowering in Huntington’s disease minipigs up to 1 year.
- Plasmin-resistant PSD-95 inhibitors resolve effect-modifying drug-drug interactions between alteplase and nerinetide in acute stroke
The plasma stability and neuroprotective effectiveness of nerinetide are enhanced by partially substituting l- to d-amino acids.
- Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy
The mitophagy inducer urolithin A reverts muscular dystrophies.
Review
- Druggable cancer phosphatases
Progress has been made in pharmacological targeting of tumor suppressor and oncogenic phosphatases for cancer therapy.
About The Cover
ONLINE COVER Taking Diabetes Down a Notch. The image shows a cross-section of pancreas from a healthy mouse exposed to anti-serpinB13 monoclonal antibodies during embryonic development. Kryvalap et al. found that antibody-mediated inhibition of serpinB13 decreased Notch signaling and increased pancreatic progenitor cell formation in mice, resulting in enhanced β cell mass as indicated by increased staining for insulin (pink) and resistance to streptozocin-induced diabetes later in adulthood. Presence of anti-serpinB13 autoantibodies was associated with delayed type 1 diabetes in children, hinting at the prophylactic potential of targeting serpinB13 in humans. [CREDIT: KRYVALAP ET AL./SCIENCE TRANSLATIONAL MEDICINE]
