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Research ArticleMICROBIOTA
Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health
- View ORCID ProfileSilvia Ribo1,*,
- View ORCID ProfileDavid Sánchez-Infantes1,2,3,*,
- Laura Martinez-Guino1,
- Izaskun García-Mantrana4,
- View ORCID ProfileMarta Ramon-Krauel1,
- Mireia Tondo5,
- View ORCID ProfileErland Arning5,
- View ORCID ProfileMiquel Nofrarías6,
- View ORCID ProfileÓscar Osorio-Conles1,
- View ORCID ProfileAntonio Fernández-Pérez7,8,†,
- View ORCID ProfilePedro González-Torres9,
- Judith Cebrià1,
- View ORCID ProfileAleix Gavaldà-Navarro3,10,11,
- View ORCID ProfileEmpar Chenoll12,
- Elvira Isganaitis13,
- View ORCID ProfileFrancesc Villarroya3,10,11,
- View ORCID ProfileMario Vallejo7,8,
- View ORCID ProfileJoaquim Segalés14,15,
- Josep C. Jiménez-Chillarón1,
- View ORCID ProfileTeodoro Bottiglieri5,
- View ORCID ProfileEllen W. Demerath16,
- View ORCID ProfileDavid A. Fields17,
- View ORCID ProfileMaría Carmen Collado4 and
- View ORCID ProfileCarles Lerin1,‡
- 1Endocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
- 2Department of Endocrinology and Nutrition, Institut de Recerca Germans Trias i Pujol, 08916 Barcelona, Spain.
- 3CIBER Fisiopatologia de la Obesidad y Nutrición, 28029 Madrid, Spain.
- 4Department of Biotechnology, Institute of Agrochemistry and Food Technology–National Research Council (IATA-CSIC), 46980 Valencia, Spain.
- 5Institute of Metabolic Disease, Baylor Scott and White Research Institute, Dallas, TX 75204, USA.
- 6IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
- 7Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas/Universidad Autónoma de Madrid (CSIC/UAM), 28029 Madrid, Spain.
- 8CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28029 Madrid, Spain.
- 9Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain.
- 10Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain.
- 11Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
- 12Biopolis S.L.-ADM, 46980 Paterna, Spain.
- 13Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
- 14UAB, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
- 15Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, 08193 Bellaterra, Barcelona, Spain.
- 16Division of Epidemiology and Community Health, The University of Minnesota School of Public Health, Minneapolis, MN 55455, USA.
- 17Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
- ↵‡Corresponding author. Email: clerin{at}fsjd.org
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Science Translational Medicine 31 Mar 2021:
Vol. 13, Issue 587, eabb0322
DOI: 10.1126/scitranslmed.abb0322
Vol. 13, Issue 587, eabb0322
DOI: 10.1126/scitranslmed.abb0322
Silvia Ribo
1Endocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
David Sánchez-Infantes
1Endocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
2Department of Endocrinology and Nutrition, Institut de Recerca Germans Trias i Pujol, 08916 Barcelona, Spain.
3CIBER Fisiopatologia de la Obesidad y Nutrición, 28029 Madrid, Spain.
Laura Martinez-Guino
1Endocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
Izaskun García-Mantrana
4Department of Biotechnology, Institute of Agrochemistry and Food Technology–National Research Council (IATA-CSIC), 46980 Valencia, Spain.
Marta Ramon-Krauel
1Endocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
Mireia Tondo
5Institute of Metabolic Disease, Baylor Scott and White Research Institute, Dallas, TX 75204, USA.
Erland Arning
5Institute of Metabolic Disease, Baylor Scott and White Research Institute, Dallas, TX 75204, USA.
Miquel Nofrarías
6IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Óscar Osorio-Conles
1Endocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
Antonio Fernández-Pérez
7Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas/Universidad Autónoma de Madrid (CSIC/UAM), 28029 Madrid, Spain.
8CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28029 Madrid, Spain.
Pedro González-Torres
9Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain.
Judith Cebrià
1Endocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
Aleix Gavaldà-Navarro
3CIBER Fisiopatologia de la Obesidad y Nutrición, 28029 Madrid, Spain.
10Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain.
11Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
Empar Chenoll
12Biopolis S.L.-ADM, 46980 Paterna, Spain.
Elvira Isganaitis
13Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
Francesc Villarroya
3CIBER Fisiopatologia de la Obesidad y Nutrición, 28029 Madrid, Spain.
10Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain.
11Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
Mario Vallejo
7Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas/Universidad Autónoma de Madrid (CSIC/UAM), 28029 Madrid, Spain.
8CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28029 Madrid, Spain.
Joaquim Segalés
14UAB, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
15Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, 08193 Bellaterra, Barcelona, Spain.
Josep C. Jiménez-Chillarón
1Endocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
Teodoro Bottiglieri
5Institute of Metabolic Disease, Baylor Scott and White Research Institute, Dallas, TX 75204, USA.
Ellen W. Demerath
16Division of Epidemiology and Community Health, The University of Minnesota School of Public Health, Minneapolis, MN 55455, USA.
David A. Fields
17Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
María Carmen Collado
4Department of Biotechnology, Institute of Agrochemistry and Food Technology–National Research Council (IATA-CSIC), 46980 Valencia, Spain.
Carles Lerin
1Endocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
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