Research ArticleMICROBIOTA

Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health

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Science Translational Medicine  31 Mar 2021:
Vol. 13, Issue 587, eabb0322
DOI: 10.1126/scitranslmed.abb0322

Article Information

vol. 13 no. 587

PubMed: 
Print ISSN: 
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History: 
  • Received for publication January 29, 2020
  • Resubmitted August 10, 2020
  • Accepted for publication November 20, 2020
  • .

Author Information

  1. Silvia Ribo1,*,
  2. David Sánchez-Infantes1,2,3,*,
  3. Laura Martinez-Guino1,
  4. Izaskun García-Mantrana4,
  5. Marta Ramon-Krauel1,
  6. Mireia Tondo5,
  7. Erland Arning5,
  8. Miquel Nofrarías6,
  9. Óscar Osorio-Conles1,
  10. Antonio Fernández-Pérez7,8,,
  11. Pedro González-Torres9,
  12. Judith Cebrià1,
  13. Aleix Gavaldà-Navarro3,10,11,
  14. Empar Chenoll12,
  15. Elvira Isganaitis13,
  16. Francesc Villarroya3,10,11,
  17. Mario Vallejo7,8,
  18. Joaquim Segalés14,15,
  19. Josep C. Jiménez-Chillarón1,
  20. Teodoro Bottiglieri5,
  21. Ellen W. Demerath16,
  22. David A. Fields17,
  23. María Carmen Collado4 and
  24. Carles Lerin1,
  1. 1Endocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
  2. 2Department of Endocrinology and Nutrition, Institut de Recerca Germans Trias i Pujol, 08916 Barcelona, Spain.
  3. 3CIBER Fisiopatologia de la Obesidad y Nutrición, 28029 Madrid, Spain.
  4. 4Department of Biotechnology, Institute of Agrochemistry and Food Technology–National Research Council (IATA-CSIC), 46980 Valencia, Spain.
  5. 5Institute of Metabolic Disease, Baylor Scott and White Research Institute, Dallas, TX 75204, USA.
  6. 6IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
  7. 7Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas/Universidad Autónoma de Madrid (CSIC/UAM), 28029 Madrid, Spain.
  8. 8CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28029 Madrid, Spain.
  9. 9Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain.
  10. 10Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain.
  11. 11Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.
  12. 12Biopolis S.L.-ADM, 46980 Paterna, Spain.
  13. 13Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
  14. 14UAB, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
  15. 15Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, 08193 Bellaterra, Barcelona, Spain.
  16. 16Division of Epidemiology and Community Health, The University of Minnesota School of Public Health, Minneapolis, MN 55455, USA.
  17. 17Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
  1. Corresponding author. Email: clerin{at}fsjd.org
  • * These authors contributed equally to this work as co–first authors.

  • Present address: Centro para el Desarrollo Tecnológico e Industrial (CDTI), 28001 Madrid, Spain.

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