Research ArticleHYDROCEPHALUS

Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice

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Science Translational Medicine  31 Mar 2021:
Vol. 13, Issue 587, eaay7896
DOI: 10.1126/scitranslmed.aay7896

Article Information

vol. 13 no. 587

PubMed: 
Print ISSN: 
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History: 
  • Received for publication July 19, 2019
  • Resubmitted July 13, 2020
  • Accepted for publication January 8, 2021
  • .

Author Information

  1. Naofumi Ito1,2,*,
  2. M. Asrafuzzaman Riyadh1,2,3,*,
  3. Shah Adil Ishtiyaq Ahmad1,2,4,*,
  4. Satoko Hattori5,
  5. Yonehiro Kanemura6,
  6. Hiroshi Kiyonari7,
  7. Takaya Abe7,
  8. Yasuhide Furuta7,8,
  9. Yohei Shinmyo1,2,9,
  10. Naoko Kaneko10,
  11. Yuki Hirota10,11,
  12. Giuseppe Lupo12,
  13. Jun Hatakeyama13,
  14. Felemban Athary Abdulhaleem M1,2,14,
  15. Mohammad Badrul Anam1,2,15,
  16. Masahiro Yamaguchi16,
  17. Toru Takeo17,
  18. Hirohide Takebayashi18,
  19. Minoru Takebayashi19,
  20. Yuichi Oike20,
  21. Naomi Nakagata17,
  22. Kenji Shimamura13,
  23. Michael J. Holtzman21,
  24. Yoshiko Takahashi22,23,
  25. Francois Guillemot24,
  26. Tsuyoshi Miyakawa5,
  27. Kazunobu Sawamoto10,25 and
  28. Kunimasa Ohta1,2,15,23,26,
  1. 1Department of Developmental Neurobiology, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
  2. 2Stem Cell-Based Tissue Regeneration Research and Education Unit, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
  3. 3Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia.
  4. 4Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Tangail-1902, Bangladesh.
  5. 5Division of System Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake 470-1192, Japan.
  6. 6Department of Biomedical Research and Innovation, Institute for Clinical Research, National Hospital Organization Osaka National Hospital, 2-1-14, Hoensaka, Chuo-ku, Osaka 540-0006, Japan.
  7. 7Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima Minami-machi,Chuou-ku, Kobe 650-0047, Japan.
  8. 8Mouse Genetics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.
  9. 9Department of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University, 13-1, Takara-cho, Ishikawa 920-8640, Japan.
  10. 10Department of Developmental and Regenerative Neurobiology, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
  11. 11Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
  12. 12Department of Biology and Biotechnology “C. Darwin”, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
  13. 13Department of Brain Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
  14. 14Department of Biology, Faculty of Applied Science, Umm Al-Qura University, 21955, Makkah, Saudi Arabia.
  15. 15Program for Leading Graduate Schools “HIGO Program”, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
  16. 16Department of Physiology, Kochi Medical School, Kochi University, Kochi 783-8505, Japan.
  17. 17Division of Reproductive Engineering, Center for Animal Resources and Development (CARD), Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.
  18. 18Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi, Chuo-ku, Niigata 951-8510, Japan.
  19. 19Department of Neuropsychiatry, Faculty of Life Science, Kumamoto University, Kumamoto 860-8556, Japan.
  20. 20Department of Molecular Genetics, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
  21. 21Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110-1093, USA.
  22. 22Department of Zoology, Graduate School of Science, Kyoto University, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan.
  23. 23AMED Core Research for Evolutional Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development (AMED), Chiyoda-ku, Tokyo 100-0004, Japan.
  24. 24The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  25. 25Division of Neural Development and Regeneration, National Institute for Physiological Sciences, Okazaki 444-8585, Japan.
  26. 26Department of Stem Cell Biology, Faculty of Arts and Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
  1. Corresponding author. Email: ohta9203{at}artsci.kyushu-u.ac.jp
  • * These authors contributed equally to this work.

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