Contents
24 March 2021
Vol 13, Issue 586
Vol 13, Issue 586
Perspective
- Reproducibility in machine learning for health research: Still a ways to go
Machine learning applied to health falls short on several reproducibility metrics compared to other machine learning subfields.
Research Articles
- SVEP1 is a human coronary artery disease locus that promotes atherosclerosis
Reducing SVEP1 confers protection from atherosclerosis and may be a therapeutic target for the treatment and prevention of coronary artery disease.
- An intracortical neuroprosthesis immediately alleviates walking deficits and improves recovery of leg control after spinal cord injury
Phase-coherent intracortical stimulation immediately alleviates foot-drop and fosters recovery of leg control in incomplete spinal cord injury rats.
- Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability
FGD5 promotes basal-like breast cancer tumorigenesis and progression by inducing and maintaining cancer stemness in an EGFR-dependent manner.
- Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors
T cells engineered with synthetic receptors that integrate components of T cell and B cell receptors show efficacy against solid tumors in mice.
- Trispecific CD19-CD20-CD22–targeting duoCAR-T cells eliminate antigen-heterogeneous B cell tumors in preclinical models
Trispecific duoCAR-T cells with optimized costimulatory domains effectively kill tumor cells in antigen-heterogeneous and antigen-replete tumor models.
- Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia
The clinically approved drugs ticagrelor and oseltamivir fortify a pathway of platelet-mediated immunity to clear staphylococcal bacteremia in mice.
About The Cover
ONLINE COVER Proliferation in Plaques. This immunofluorescence image shows a marker of proliferation (minichromosome maintenance protein–2, cyan) and smooth muscle α-actin (red) in a mouse aorta; nuclei are counterstained blue. Jung et al. studied how the extracellular matrix protein sushi, von Willebrand factor type A, EGF, and pentraxin domain-containing protein 1 (SVEP1) contributes to atherosclerosis. They observed less proliferation of vascular smooth muscle cells, reduced inflammation, and smaller plaques in mice lacking transcription of the Svep1 gene in vascular smooth muscle cells. Human plasma samples showed that high SVEP1 concentration was associated with increased risk of coronary artery disease. These results suggest that targeting SVEP1 could be therapeutic for atherosclerosis. [CREDIT: JUNG ET AL./SCIENCE TRANSLATIONAL MEDICINE]
