Research ArticleHIV

Effector function does not contribute to protection from virus challenge by a highly potent HIV broadly neutralizing antibody in nonhuman primates

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Science Translational Medicine  17 Mar 2021:
Vol. 13, Issue 585, eabe3349
DOI: 10.1126/scitranslmed.abe3349

Article Information

vol. 13 no. 585

Print ISSN: 
Online ISSN: 
  • Received for publication September 1, 2020
  • Resubmitted December 3, 2020
  • Accepted for publication February 3, 2021
  • .

Author Information

  1. Lars Hangartner1,2,*,
  2. David Beauparlant1,
  3. Eva Rakasz3,
  4. Rebecca Nedellec1,
  5. Nathanaël Hozé4,5,,
  6. Katherine McKenney1,
  7. Mauricio A. Martins6,
  8. Gemma E. Seabright7,8,
  9. Joel D. Allen7,
  10. Andrea M. Weiler3,
  11. Thomas C. Friedrich3,
  12. Roland R. Regoes4,5,
  13. Max Crispin7 and
  14. Dennis R. Burton1,2,9,10,*
  1. 1Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  2. 2Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.
  3. 3Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Court, Madison, WI 53715, USA.
  4. 4Institute of Integrative Biology (IBZ), ETH Zurich, ETH Zentrum, CHN H76.2, Universitätstrasse 16, 8092 Zurich, Switzerland.
  5. 5Theoretical Biology, ETH Zurich, ETH Zentrum, CHN K12.2, Universitätstrasse 16, 8092 Zurich, Switzerland.
  6. 6Department of Immunology and Microbiology, Scripps Research, Jupiter, FL 33458, USA.
  7. 7School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK.
  8. 8Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
  9. 9IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
  10. 10Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard University, Cambridge, MA 02139, USA.
  1. *Corresponding author. Email: lhangart{at} (L.H.); burton{at} (D.R.B.)
  • Present address: Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, UMR2000, CNRS, 75015 Paris, France.


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