Contents
17 March 2021
Vol 13, Issue 585
Vol 13, Issue 585
Research Articles
- Effector function does not contribute to protection from virus challenge by a highly potent HIV broadly neutralizing antibody in nonhuman primates
Effector function is not required for a potent HIV envelope–specific broadly neutralizing antibody to protect nonhuman primates from SHIV infection.
- Graft-derived extracellular vesicles transported across subcapsular sinus macrophages elicit B cell alloimmunity after transplantation
B cell sensitization to allografts is promoted by graft-derived extracellular vesicles concentrated by specialized macrophages in lymphoid tissues.
- Pediatric tri-tube valved conduits made from fibroblast-produced extracellular matrix evaluated over 52 weeks in growing lambs
A pulmonary replacement valve made from three tubes of cell-derived matrix functioned for 52 weeks in lambs and calcified less than commercial valves.
- GDE2-RECK controls ADAM10 α-secretase–mediated cleavage of amyloid precursor protein
GDE2 controls surface amounts of the metalloprotease inhibitor RECK to promote ADAM10 α-secretase activity and prevent Aβ production and synapse loss.
- RNA-seq of human T cells after hematopoietic stem cell transplantation identifies Linc00402 as a regulator of T cell alloimmunity
LncRNAs are differentially expressed by allogeneic antigen-stimulated T cells, and Linc00402 regulates allogeneic T cells.
- Structure-switching aptamer sensors for the specific detection of piperaquine and mefloquine
Aptamer-based fluorescent sensors specifically detect the antimalarial drugs piperaquine and mefloquine from patient samples and crushed tablets.
- Citrullinated vimentin mediates development and progression of lung fibrosis
Cd/CB-induced citrullinated vimentin promotes PAD2- and TLR4-dependent lung fibrosis.
Perspective
- Advanced bandages for diabetic wound healing
This Perspective discusses recently identified targets to enhance diabetic wound healing and their incorporation into wound dressings.
About The Cover
ONLINE COVER Necessary Neutralization. This image depicts a human immunodeficiency virus (HIV) broadly neutralizing antibody, PGT121 (blue), bound to an Fc receptor (red) and interacting with HIV envelope protein on the surface of an infected cell (white and teal). In this study, Hangartner et al. treated rhesus macaques with variants of PGT121 that are unable to bind Fc receptors to understand if Fc receptor binding is required to mediate protection by PGT121. They found that variants which can only function by neutralization were equally effective at protecting female macaques against intravaginal simian-HIV infection. These results demonstrate that certain broadly neutralizing antibodies may not require Fc receptors to mediate protection. [CREDIT: L. HANGARTNER AND C. CORBACI/THE SCRIPPS RESEARCH INSTITUTE]
