Research ArticleAtherosclerosis

Prosaposin mediates inflammation in atherosclerosis

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Science Translational Medicine  10 Mar 2021:
Vol. 13, Issue 584, eabe1433
DOI: 10.1126/scitranslmed.abe1433

Article Information

vol. 13 no. 584

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 3, 2020
  • Resubmitted November 17, 2020
  • Accepted for publication February 17, 2021
  • .

Author Information

  1. Mandy M. T. van Leent1,2,
  2. Thijs J. Beldman2,3,
  3. Yohana C. Toner1,
  4. Marnix A. Lameijer1,2,
  5. Nils Rother4,
  6. Siroon Bekkering3,
  7. Abraham J. P. Teunissen1,
  8. Xianxiao Zhou5,
  9. Roy van der Meel6,
  10. Joost Malkus1,
  11. Sheqouia A. Nauta1,
  12. Emma D. Klein1,
  13. Francois Fay1,7,
  14. Brenda L. Sanchez-Gaytan1,8,
  15. Carlos Pérez-Medina1,9,
  16. Ewelina Kluza6,
  17. Yu-Xiang Ye10,11,
  18. Gregory Wojtkiewicz10,
  19. Edward A. Fisher12,
  20. Filip K. Swirski10,
  21. Matthias Nahrendorf10,
  22. Bin Zhang5,
  23. Yang Li3,13,
  24. Bowen Zhang13,
  25. Leo A. B. Joosten3,14,
  26. Gerard Pasterkamp15,
  27. Arjan Boltjes15,
  28. Zahi A. Fayad1,
  29. Esther Lutgens2,16,17,
  30. Mihai G. Netea3,18,
  31. Niels P. Riksen3,
  32. Willem J. M. Mulder1,3,6,19 and
  33. Raphaël Duivenvoorden1,4,*
  1. 1Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  2. 2Experimetal Vascular Biology, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, 1105 AZ Amsterdam, Netherlands.
  3. 3Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
  4. 4Department of Nephrology and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
  5. 5Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  6. 6Department of Chemical Biology, Eindhoven University of Technology, 5612 AZ Eindhoven, Netherlands.
  7. 7Institut Galien Paris-Saclay, Faculté de Pharmacie, CNRS, Université Paris-Saclay, 92 296 Châtenay-Malabry, France.
  8. 8Chemistry Center, Science Institute, Meritorious Autonomous University of Puebla, Puebla 72570, Mexico.
  9. 9Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
  10. 10Center for Systems Biology, Massachusetts General Hospital Research Institute and Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.
  11. 11Department of Diagnostic and Interventional Radiology, University Hospitals Tuebingen, 72076 Tuebingen, Germany.
  12. 12Department of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, NYU School of Medicine, New York, NY 10016, USA.
  13. 13Centre for Individualised Infection Medicine (CiiM) and TWINCORE, joint ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), 30625 Hannover, Germany.
  14. 14Department of Medical Genetics, University of Medicine and Pharmacy, Iuliu Haţieganu, Cluj-Napoca 400000, Romania.
  15. 15Central Diagnostics Laboratory, Division Laboratories and Pharmacy, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.
  16. 16Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians Universität, 80331 Munich, Germany.
  17. 17German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, 80539 Munich, Germany.
  18. 18Department for Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, 53127 Bonn, Germany.
  19. 19Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  1. *Corresponding author. Email: raphael.duivenvoorden{at}radboudumc.nl

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