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A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma

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Science Translational Medicine  10 Mar 2021:
Vol. 13, Issue 584, eabb3945
DOI: 10.1126/scitranslmed.abb3945

Article Information

vol. 13 no. 584

PubMed: 
Print ISSN: 
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History: 
  • Received for publication February 20, 2020
  • Accepted for publication February 19, 2021
  • .

Author Information

  1. Priya Kumthekar1,*,
  2. Caroline H. Ko2,,
  3. Tatjana Paunesku3,
  4. Karan Dixit1,
  5. Adam M. Sonabend4,
  6. Orin Bloch4,
  7. Matthew Tate4,
  8. Margaret Schwartz1,
  9. Laura Zuckerman1,
  10. Ray Lezon1,
  11. Rimas V. Lukas1,
  12. Borko Jovanovic5,
  13. Kathleen McCortney4,
  14. Howard Colman6,
  15. Si Chen7,
  16. Barry Lai7,
  17. Olga Antipova7,
  18. Junjing Deng7,
  19. Luxi Li7,
  20. Serena Tommasini-Ghelfi1,
  21. Lisa A. Hurley1,
  22. Dusten Unruh4,
  23. Nitya V. Sharma8,
  24. Manoj Kandpal9,
  25. Fotini M. Kouri1,
  26. Ramana V. Davuluri9,
  27. Daniel J. Brat8,
  28. Miguel Muzzio10,
  29. Mitchell Glass11,
  30. Vinod Vijayakumar11,
  31. Jeremy Heidel12,
  32. Francis J. Giles13,
  33. Ann K. Adams14,
  34. C. David James4,
  35. Gayle E. Woloschak3,
  36. Craig Horbinski4,8 and
  37. Alexander H. Stegh1,2,*
  1. 1Ken and Ruth Davee Department of Neurology, The Northwestern Malnati Brain Tumor Institute, Feinberg School of Medicine, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
  2. 2International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208, USA.
  3. 3Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  4. 4Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  5. 5Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  6. 6Huntsman Cancer Institute and Department of Neurosurgery, University of Utah, Salt Lake City, UT 84112, USA.
  7. 7X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439, USA.
  8. 8Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  9. 9Preventive Medicine, Health and Biomedical Informatics, Feinberg School of Medicine, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
  10. 10Life Sciences Group, IIT Research Institute, Chicago, IL 60616, USA.
  11. 11Broom Street Associates, Wilmington, DE 19806, USA.
  12. 12Informulate LLC, Madison, WI 53704, USA.
  13. 13Developmental Therapeutics Program of the Division of Hematology Oncology, Feinberg School of Medicine, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
  14. 14Office for Research, Northwestern University, Evanston, IL 60208, USA.
  1. *Corresponding author. Email: priya.kumthekar{at}nm.org (P.K.); a-stegh{at}northwestern.edu (A.H.S.)
  • Present address: NewCures Accelerator, Northwestern University, Evanston, IL 60201, USA.

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Article usage: March 2021 to August 2021

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Mar 2021111441357879
Apr 20212030236184
May 20211084166104
Jun 20215867967
Jul 20215267557
Aug 20214579

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