Long-lasting analgesia via targeted in situ repression of NaV1.7 in mice

Ana M. Moreno; Fernando Alemán; Glaucilene F. Catroli; Matthew Hunt; Michael Hu; Amir Dailamy; Andrew Pla; Sarah A. Woller; Nathan Palmer; Udit Parekh; Daniella McDonald; Amanda J. Roberts; Vanessa Goodwill; Ian Dryden; Robert F. Hevner; Lauriane Delay; Gilson Gonçalves dos Santos; Tony L. Yaksh; Prashant Mali

doi:10.1126/scitranslmed.aay9056

Research ArticlePain

Long-lasting analgesia via targeted in situ repression of Na_V1.7 in mice

View ORCID ProfileAna M. Moreno¹,*,
View ORCID ProfileFernando Alemán¹,*,
View ORCID ProfileGlaucilene F. Catroli²,
View ORCID ProfileMatthew Hunt²,
View ORCID ProfileMichael Hu¹,
View ORCID ProfileAmir Dailamy¹,
Andrew Pla¹,
View ORCID ProfileSarah A. Woller²,†,
View ORCID ProfileNathan Palmer³,
View ORCID ProfileUdit Parekh⁴,
Daniella McDonald¹,⁵,
View ORCID ProfileAmanda J. Roberts⁶,
Vanessa Goodwill⁷,
View ORCID ProfileIan Dryden⁷,
View ORCID ProfileRobert F. Hevner⁷,
View ORCID ProfileLauriane Delay²,
View ORCID ProfileGilson Gonçalves dos Santos²,
View ORCID ProfileTony L. Yaksh ²,‡ and
View ORCID ProfilePrashant Mali ¹,‡

¹Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.
²Department of Anesthesiology, University of California San Diego, San Diego, CA 92093, USA.
³Division of Biological Sciences, University of California San Diego , San Diego, CA 92093, USA.
⁴Department of Electrical Engineering, University of California San Diego , San Diego, CA 92093, USA.
⁵Biomedical Sciences Graduate Program, University of California San Diego, San Diego, San Diego, CA 92093, USA.
⁶Animal Models Core, Scripps Research Institute, La Jolla, CA 92037, USA.
⁷Department of Neuropathology, University of California San Diego, San Diego, CA 92093, USA.

↵‡Corresponding author. Email: pmali{at}ucsd.edu (P.M.); tyaksh{at}ucsd.edu (T.L.Y.)

↵* Present address: Navega Therapeutics, San Diego, CA 92121, USA.
↵† Present address: National Institutes of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, MD 20852, USA.

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Science Translational Medicine 10 Mar 2021:
Vol. 13, Issue 584, eaay9056
DOI: 10.1126/scitranslmed.aay9056

Ana M. Moreno

1Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.

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Fernando Alemán

1Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.

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Glaucilene F. Catroli

2Department of Anesthesiology, University of California San Diego, San Diego, CA 92093, USA.

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Matthew Hunt

2Department of Anesthesiology, University of California San Diego, San Diego, CA 92093, USA.

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Michael Hu

1Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.

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Amir Dailamy

1Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.

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Andrew Pla

1Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.

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Sarah A. Woller

2Department of Anesthesiology, University of California San Diego, San Diego, CA 92093, USA.

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Nathan Palmer

3Division of Biological Sciences, University of California San Diego , San Diego, CA 92093, USA.

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Udit Parekh

4Department of Electrical Engineering, University of California San Diego , San Diego, CA 92093, USA.

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Daniella McDonald

1Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.

5Biomedical Sciences Graduate Program, University of California San Diego, San Diego, San Diego, CA 92093, USA.

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Amanda J. Roberts

6Animal Models Core, Scripps Research Institute, La Jolla, CA 92037, USA.

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Vanessa Goodwill

7Department of Neuropathology, University of California San Diego, San Diego, CA 92093, USA.

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Ian Dryden

7Department of Neuropathology, University of California San Diego, San Diego, CA 92093, USA.

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Robert F. Hevner

7Department of Neuropathology, University of California San Diego, San Diego, CA 92093, USA.

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Lauriane Delay

2Department of Anesthesiology, University of California San Diego, San Diego, CA 92093, USA.

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Gilson Gonçalves dos Santos

2Department of Anesthesiology, University of California San Diego, San Diego, CA 92093, USA.

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Tony L. Yaksh

2Department of Anesthesiology, University of California San Diego, San Diego, CA 92093, USA.

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For correspondence: pmali@ucsd.edu tyaksh@ucsd.edu

Prashant Mali

1Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.

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For correspondence: pmali@ucsd.edu tyaksh@ucsd.edu

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Long-lasting analgesia via targeted in situ repression of Na_V1.7 in mice

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