03 March 2021
Vol 13, Issue 583

About The Cover

Cover image expansion

ONLINE COVER Inhibiting Tumor Angiogenesis. This immunofluorescence image of a subcutaneously transplanted Lewis lung carcinoma mouse tumor reveals an abundance of endothelial cells (red; nuclei are stained blue and tumor cells are stained green) that are dependent on Myct1. Kabir et al. investigated mediators of angiogenesis within the tumor microenvironment, finding that Myct1 was expressed in endothelial cells and was critical to tumor growth. The protein product of this gene, MYC Target 1 (MYCT1), was also found to promote an immunosuppressive tumor microenvironment, revealing a dual role for the protein. In combination with immune checkpoint inhibitor treatment, Myct1 knockdown resulted in tumor regression and long-term survival of mice, suggesting that MYCT1 could be a target for cancer therapy. [CREDIT: KABIR ET AL./SCIENCE TRANSLATIONAL MEDICINE]