Research ArticleCancer

Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment-resistant MLL-rearranged leukemia

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Science Translational Medicine  24 Feb 2021:
Vol. 13, Issue 582, eabc4822
DOI: 10.1126/scitranslmed.abc4822

Article Information

vol. 13 no. 582

Print ISSN: 
Online ISSN: 
  • Received for publication April 28, 2020
  • Accepted for publication January 8, 2021
  • .

Author Information

  1. Bernd B. Zeisig1,2,*,
  2. Tsz Kan Fung1,2,*,
  3. Magdalena Zarowiecki1,,
  4. Chiou Tsun Tsai1,
  5. Huacheng Luo3,
  6. Boban Stanojevic1,4,
  7. Claire Lynn1,,
  8. Anskar Y. H. Leung5,
  9. Jan Zuna6,
  10. Marketa Zaliova6,
  11. Martin Bornhauser7,
  12. Malte von Bonin7,
  13. Boris Lenhard8,9,10,
  14. Suming Huang3,§,
  15. Ghulam J. Mufti1,2 and
  16. Chi Wai Eric So1,2,§,||
  1. 1Leukaemia and Stem Cell Biology Group, School of Cancer and Pharmaceutical Sciences, King’s College, London SE5 9NU, UK.
  2. 2Department of Haematological Medicine, King’s College Hospital, London SE5 9RS, UK.
  3. 3Division of Pediatric Hematology/Oncology, Department of Pediatrics, Penn State Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
  4. 4Laboratory for Radiobiology and Molecular Genetics, Vinca Institute of Nuclear Science, University of Belgrade, 11000 Belgrade, Serbia.
  5. 5Department of Medicine, The University of Hong Kong, Pokfulam Road, HKSAR, China.
  6. 6CLIP, Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, 150 06 Prague 5, Czech Republic.
  7. 7Department of Medicine, University Hospital, 01307 Dresden, Germany.
  8. 8Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, UK.
  9. 9Computational Regulatory Genomics, MRC London Institute of Medical Sciences, London W12 0NN, UK.
  10. 10Sars International Centre for Marine Molecular Biology, University of Bergen, N-5008 Bergen, Norway.
  1. §Corresponding author. Email:{at} (C.W.E.S.); shuang4{at} (S.H.)
  • * These authors contributed equally to this work.

  • Present address: Genomics England, Queen Mary University of London, London EC1M 6BQ, UK.

  • Present address: Evolutionary Genomics and Modelling, Department of Molecular Pathology, Institute of Cancer Research, London SW7 3RP, UK.

  • || Lead contact.


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