24 February 2021
Vol 13, Issue 582

About The Cover

Cover image expansion

ONLINE COVER Insights into Nephrotoxicity. This image shows a cross section of a three-dimensional polarized human kidney proximal tubule cyst (green, aquaporin-1; red, actin; blue, nuclear stain). Cohen et al. studied drug-induced nephrotoxicity using vascularized human kidney cell spheroids in vitro. Exposure to cyclosporine and cisplatin disrupted cell polarity and caused toxicity due to glucose accumulation, which could be counteracted by inhibiting glucose reabsorption. Better kidney function and reduced markers of kidney damage were seen in patients treated with cyclosporine or cisplatin and sodium-glucose cotransporter-2 inhibition, demonstrating the utility of this kidney spheroid platform to investigate mechanisms of drug-induced toxicity. [CREDIT: YAAKOV NAHMIAS/THE HEBREW UNIVERSITY OF JERUSALEM]