Research ArticleCARDIOMYOPATHY

Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy

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Science Translational Medicine  17 Feb 2021:
Vol. 13, Issue 581, eabf0891
DOI: 10.1126/scitranslmed.abf0891

Article Information

vol. 13 no. 581

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 2, 2020
  • Accepted for publication January 27, 2021
  • .

Author Information

  1. Stephen P. Chelko1,2,*,
  2. Gizem Keceli2,
  3. Andrea Carpi3,
  4. Nunzianna Doti4,
  5. Jacopo Agrimi2,
  6. Angeliki Asimaki5,
  7. Carlos Bueno Beti5,
  8. Matthew Miyamoto2,
  9. Nuria Amat-Codina2,
  10. Djahida Bedja2,6,
  11. An-Chi Wei2,
  12. Brittney Murray2,
  13. Crystal Tichnell2,
  14. Chulan Kwon2,
  15. Hugh Calkins2,
  16. Cynthia A. James2,
  17. Brian O’Rourke2,
  18. Marc K. Halushka7,
  19. Edon Melloni8,
  20. Jeffrey E. Saffitz9,
  21. Daniel P. Judge2,10,
  22. Menotti Ruvo4,
  23. Richard N. Kitsis11,
  24. Peter Andersen2,
  25. Fabio Di Lisa3 and
  26. Nazareno Paolocci2,3,*
  1. 1Department of Biomedical Sciences, Florida State University, Tallahassee, FL 32306, USA.
  2. 2Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  3. 3Department of Biomedical Sciences, University of Padova, Padova 35122, Italy.
  4. 4Institute of Biostructures and Bioimaging, CNR, Naples 80134, Italy.
  5. 5Molecular and Clinical Sciences Research Institute, St. George’s, University of London, London WC1E 6BS, UK.
  6. 6Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia.
  7. 7Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  8. 8Department of Medicine, University of Genova, Genova 16126, Italy.
  9. 9Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 20115, USA.
  10. 10Medical University of South Carolina, Charleston, SC 29425, USA.
  11. 11Departments of Medicine and Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  1. *Corresponding author. Email: stephen.chelko{at}med.fsu.edu (S.P.C.), npaoloc1{at}jhmi.edu (N.P.)

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