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Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses

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Science Translational Medicine  17 Feb 2021:
Vol. 13, Issue 581, eabd8636
DOI: 10.1126/scitranslmed.abd8636

Article Information

vol. 13 no. 581

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 16, 2020
  • Accepted for publication January 13, 2021
  • .

Author Information

  1. Jennifer A. Lo1,2,
  2. Masayoshi Kawakubo1,*,
  3. Vikram R. Juneja3,4,*,
  4. Mack Y. Su1,2,*,
  5. Tal H. Erlich1,2,*,
  6. Martin W. LaFleur3,4,5,
  7. Lajos V. Kemeny1,2,
  8. Mamunur Rashid6,
  9. Mohsen Malehmir7,
  10. S. Alireza Rabi7,
  11. Rumya Raghavan8,9,
  12. Jennifer Allouche1,2,
  13. Gyulnara Kasumova7,
  14. Dennie T. Frederick7,
  15. Kristen E. Pauken3,4,
  16. Qing Yu Weng1,2,
  17. Marcelo Pereira da Silva1,
  18. Yu Xu10,
  19. Anita A. J. van der Sande1,2,
  20. Whitney Silkworth1,2,
  21. Elisabeth Roider1,2,11,12,13,
  22. Edward P. Browne14,
  23. David J. Lieb8,
  24. Belinda Wang8,15,
  25. Levi A. Garraway8,15,
  26. Catherine J. Wu8,15,
  27. Keith T. Flaherty2,
  28. Constance E. Brinckerhoff16,
  29. David W. Mullins17,
  30. David J. Adams6,
  31. Nir Hacohen2,8,
  32. Mai P. Hoang18,
  33. Genevieve M. Boland7,,
  34. Gordon J. Freeman15,19,,
  35. Arlene H. Sharpe3,4,8,,
  36. Dieter Manstein1, and
  37. David E. Fisher1,2,
  1. 1Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  2. 2Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
  3. 3Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
  4. 4Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, USA.
  5. 5Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.
  6. 6Experimental Cancer Genetics, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.
  7. 7Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  8. 8Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  9. 9Harvard-MIT Health Sciences and Technology Program, Cambridge, MA 02139, USA.
  10. 10Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  11. 11Department of Dermatology and Allergology, University of Szeged, Szeged 6727, Hungary.
  12. 12Department of Dermatology, Venerology, and Allergology, Kantonsspital St. Gallen, St. Gallen 9000, Switzerland.
  13. 13University of Zurich, Zurich 8006, Switzerland.
  14. 14Department of Medicine, UNC-Chapel Hill, Chapel Hill, NC 27599, USA.
  15. 15Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  16. 16Departments of Medicine and Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
  17. 17Departments of Medical Education and Microbiology/Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
  18. 18Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  19. 19Harvard Medical School, Boston, MA 02115, USA.
  1. Corresponding author. Email: dfisher3{at}partners.org (D.E.F.); dmanstein{at}mgh.harvard.edu (D.M.); arlene_sharpe{at}hms.harvard.edu (A.H.S.); gordon_freeman{at}dfci.harvard.edu (G.J.F.); gmboland{at}partners.org (G.M.B.)
  • * These authors contributed equally to this work.

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