Research ArticleAlzheimer’s Disease

APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function

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Science Translational Medicine  17 Feb 2021:
Vol. 13, Issue 581, eabd7522
DOI: 10.1126/scitranslmed.abd7522

Article Information

vol. 13 no. 581

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 9, 2020
  • Accepted for publication October 16, 2020
  • .

Author Information

  1. Monica Xiong1,2,
  2. Hong Jiang1,
  3. Javier Remolina Serrano1,
  4. Ernesto R. Gonzales1,
  5. Chao Wang1,
  6. Maud Gratuze1,
  7. Rosa Hoyle1,
  8. Nga Bien-Ly3,
  9. Adam P. Silverman4,
  10. Patrick M. Sullivan5,
  11. Ryan J. Watts3,
  12. Jason D. Ulrich1,
  13. Gregory J. Zipfel6 and
  14. David M. Holtzman1,*
  1. 1Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
  2. 2Division of Biology and Biomedical Sciences (DBBS), Washington University School of Medicine, St. Louis, MO 63110, USA.
  3. 3Denali Therapeutics, South San Francisco, CA 94080, USA.
  4. 4Codexis, Redwood City, CA 94063, USA.
  5. 5Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  6. 6Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
  1. *Corresponding author. Email: holtzman{at}wustl.edu

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