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Research ArticleCancer
Using deep learning for dermatologist-level detection of suspicious pigmented skin lesions from wide-field images
- View ORCID ProfileLuis R. Soenksen1,2,3,4,5,*,
- Timothy Kassis6,
- View ORCID ProfileSusan T. Conover2,
- Berta Marti-Fuster2,5,
- View ORCID ProfileJudith S. Birkenfeld2,5,
- View ORCID ProfileJason Tucker-Schwartz2,5,
- Asif Naseem2,5,
- View ORCID ProfileRobert R. Stavert7,8,9,
- Caroline C. Kim10,11,
- View ORCID ProfileMaryanne M. Senna9,12,
- View ORCID ProfileJosé Avilés-Izquierdo13,
- View ORCID ProfileJames J. Collins2,3,4,6,14,15,
- View ORCID ProfileRegina Barzilay16,17 and
- View ORCID ProfileMartha L. Gray2,4,5,17
- 1Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA.
- 2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA.
- 3Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Cir, Boston, MA 02115, USA.
- 4Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA.
- 5MIT linQ, Massachusetts Institute of Technology Cambridge, MA 02148, USA.
- 6Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, 02139, MA, USA.
- 7Division of Dermatology, Cambridge Health Alliance, 1493 Cambridge Street, Cambridge, MA 02139, USA.
- 8Department of Dermatology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA.
- 9Department of Dermatology, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
- 10Pigmented Lesion Program, Newton Wellesley Dermatology Associates, 65 Walnut Street Suite 520 Wellesley Hills, MA 02481, USA.
- 11Department of Dermatology, Tufts Medical Center, 260 Tremont Street Biewend Building, Boston, MA 02116, USA.
- 12Department of Dermatology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114
- 13Department of Dermatology, Hospital General Universitario Gregorio Marañón, Calle del Dr. Esquerdo 46, 28007 Madrid, Spain.
- 14Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
- 15School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
- 16Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA.
- 17Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology Cambridge, MA 02148, USA.
- ↵*Corresponding author. Email: soenksen{at}mit.edu
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Science Translational Medicine 17 Feb 2021:
Vol. 13, Issue 581, eabb3652
DOI: 10.1126/scitranslmed.abb3652
Vol. 13, Issue 581, eabb3652
DOI: 10.1126/scitranslmed.abb3652
Luis R. Soenksen
1Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA.
2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA.
3Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Cir, Boston, MA 02115, USA.
4Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA.
5MIT linQ, Massachusetts Institute of Technology Cambridge, MA 02148, USA.
Timothy Kassis
6Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, 02139, MA, USA.
Susan T. Conover
2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA.
Berta Marti-Fuster
2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA.
5MIT linQ, Massachusetts Institute of Technology Cambridge, MA 02148, USA.
Judith S. Birkenfeld
2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA.
5MIT linQ, Massachusetts Institute of Technology Cambridge, MA 02148, USA.
Jason Tucker-Schwartz
2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA.
5MIT linQ, Massachusetts Institute of Technology Cambridge, MA 02148, USA.
Asif Naseem
2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA.
5MIT linQ, Massachusetts Institute of Technology Cambridge, MA 02148, USA.
Robert R. Stavert
7Division of Dermatology, Cambridge Health Alliance, 1493 Cambridge Street, Cambridge, MA 02139, USA.
8Department of Dermatology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA.
9Department of Dermatology, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
Caroline C. Kim
10Pigmented Lesion Program, Newton Wellesley Dermatology Associates, 65 Walnut Street Suite 520 Wellesley Hills, MA 02481, USA.
11Department of Dermatology, Tufts Medical Center, 260 Tremont Street Biewend Building, Boston, MA 02116, USA.
Maryanne M. Senna
9Department of Dermatology, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
12Department of Dermatology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114
José Avilés-Izquierdo
13Department of Dermatology, Hospital General Universitario Gregorio Marañón, Calle del Dr. Esquerdo 46, 28007 Madrid, Spain.
James J. Collins
2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA.
3Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Cir, Boston, MA 02115, USA.
4Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA.
6Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, 02139, MA, USA.
14Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
15School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
Regina Barzilay
16Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA.
17Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology Cambridge, MA 02148, USA.
Martha L. Gray
2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA.
4Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA.
5MIT linQ, Massachusetts Institute of Technology Cambridge, MA 02148, USA.
17Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology Cambridge, MA 02148, USA.
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