Research ArticleMyocardial Infarction

Elastin-like recombinamers-based hydrogel modulates post-ischemic remodeling in a non-transmural myocardial infarction in sheep

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Science Translational Medicine  17 Feb 2021:
Vol. 13, Issue 581, eaaz5380
DOI: 10.1126/scitranslmed.aaz5380

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Modulating myocardial remodeling

Acellular hydrogels have shown promise in improving cardiac function after myocardial infarction in preclinical animal models. Contessotto et al. developed a sheep model of non–ST elevation myocardial infarction, a form of infarction that does not involve the full thickness of the wall of the heart. Treating this sheep model with a degradable elastin-like polypeptide hydrogel, which mimics the extracellular matrix, reduced fibrosis and angiogenesis in the ischemic region, improved cardiac function, and maintained cardiomyocyte integrity in the border zone of infarcts. Results suggest that this hydrogel may help modulate post-ischemic cardiac remodeling.

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