Contents
17 February 2021
Vol 13, Issue 581
Vol 13, Issue 581
Research Articles
- Platelets release mitochondrial antigens in systemic lupus erythematosus
Platelets are a source of extracellular DNA and mitochondrial antigens in systemic lupus erythematosus.
- Using deep learning for dermatologist-level detection of suspicious pigmented skin lesions from wide-field images
Deep neural networks facilitate detection of suspicious pigmented lesions in wide-field images and could allow for efficient primary care screening.
- Elastin-like recombinamers-based hydrogel modulates post-ischemic remodeling in a non-transmural myocardial infarction in sheep
An injectable functionalized elastin-inspired hydrogel improves cardiac functional response in sheep and preserves cardiomyocytes in the border zone.
- APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function
Targeting APOE using an anti-APOE antibody ameliorates amyloid pathology while protecting cerebrovascular integrity and function.
- Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses
Neoantigens sensitize melanomas to checkpoint blockade and trigger epitope spreading to self-antigens, a process mimicked by combination immunotherapy.
- Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy
Exercise-induced activation of calpain and nuclear translocation of calpain-cleaved apoptotic factor AIF triggers cardiomyocyte death in ACM.
- Analysis of recurrently protected genomic regions in cell-free DNA found in urine
Fragmentation patterns of cell-free DNA from urine differ between healthy individuals and those with cancer.
About The Cover
ONLINE COVER An Anucleated Source of DNA. This image shows immunofluorescence staining of the kidney in lupus-prone mice where Antibody deposits (orange) are shown on the endothelium (red). In systemic lupus erythematosus (SLE), accumulation of DNA in blood triggers recognition by autoantibodies, but the source of DNA remains unclear. Here, Melki et al. showed that mitochondrial DNA (mtDNA) is released into the bloodstream by activated platelets in mice. Patients with SLE showed increased platelet activation and, in lupus-prone mice, triggering an antibody receptor on platelets resulted in their activation, mtDNA release, and worsening of the lupus phenotype. The results suggest that targeting platelet activation could have therapeutic relevance in SLE. [CREDIT: MELKI ET AL./SCIENCE TRANSLATIONAL MEDICINE]
