17 February 2021
Vol 13, Issue 581

About The Cover

Cover image expansion

ONLINE COVER An Anucleated Source of DNA. This image shows immunofluorescence staining of the kidney in lupus-prone mice where Antibody deposits (orange) are shown on the endothelium (red). In systemic lupus erythematosus (SLE), accumulation of DNA in blood triggers recognition by autoantibodies, but the source of DNA remains unclear. Here, Melki et al. showed that mitochondrial DNA (mtDNA) is released into the bloodstream by activated platelets in mice. Patients with SLE showed increased platelet activation and, in lupus-prone mice, triggering an antibody receptor on platelets resulted in their activation, mtDNA release, and worsening of the lupus phenotype. The results suggest that targeting platelet activation could have therapeutic relevance in SLE. [CREDIT: MELKI ET AL./SCIENCE TRANSLATIONAL MEDICINE]