Research ArticleCardiology

Cardiac ryanodine receptor calcium release deficiency syndrome

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Science Translational Medicine  03 Feb 2021:
Vol. 13, Issue 579, eaba7287
DOI: 10.1126/scitranslmed.aba7287

Article Information

vol. 13 no. 579

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  • Received for publication December 30, 2019
  • Accepted for publication December 7, 2020
  • .

Author Information

  1. Bo Sun1,2,*,
  2. Jinjing Yao1,*,
  3. Mingke Ni1,*,
  4. Jinhong Wei1,
  5. Xiaowei Zhong1,
  6. Wenting Guo1,
  7. Lin Zhang1,
  8. Ruiwu Wang1,
  9. Darrell Belke1,
  10. Yong-Xiang Chen1,
  11. Krystien V.V. Lieve3,4,
  12. Anders K. Broendberg5,
  13. Thomas M. Roston6,
  14. Ivan Blankoff7,
  15. Janneke A. Kammeraad8,
  16. Johannes C. von Alvensleben9,
  17. Julieta Lazarte10,
  18. Alexander Vallmitjana11,
  19. Loryn J. Bohne12,
  20. Robert A. Rose12,
  21. Raul Benitez11,
  22. Leif Hove-Madsen13,
  23. Carlo Napolitano4,14,15,
  24. Robert A. Hegele10,
  25. Michael Fill16,
  26. Shubhayan Sanatani17,,
  27. Arthur A.M. Wilde3,4,,
  28. Jason D. Roberts18,,
  29. Silvia G. Priori4,14,15,19,,
  30. Henrik K. Jensen5, and
  31. S. R. Wayne Chen1,16,
  1. 1Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4Z6, Canada.
  2. 2Medical School, Kunming University of Science and Technology, Kunming 650504, China.
  3. 3Amsterdam University Medical Centre, location AMC, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam 1105AZ, Netherlands.
  4. 4European Reference Network ‘ERN GUARD-Heart’, Amsterdam, Netherlands.
  5. 5Department of Cardiology, Aarhus University Hospital, and Department of Clinical Medicine, Health, Aarhus University, Palle Juul-Jensens Blv 99, DK-8200 Aarhus N, Denmark.
  6. 6Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
  7. 7C.H.U. Charleroi, Hôpital Civil Marie Curie Chaussée de Bruxelles 140 6042 Charleroi, Belgium.
  8. 8Department of Pediatric Cardiology, Sophia Children’s Hospital, Erasmus University Medical Centre, Doctor Molewaterplein 40, 3015 GD Rotterdam, Netherlands.
  9. 9Division of Cardiology, Heart Institute, Children’s Hospital Colorado, University of Colorado, Aurora, CO 80045, USA.
  10. 10Department of Medicine and Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5B7, Canada.
  11. 11Department of Automatic Control, Universitat Politècnica de Catalunya, 08034 Barcelona, Spain.
  12. 12Departments of Cardiac Sciences and Physiology and Pharmacology, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada.
  13. 13Biomedical Research Institute Barcelona (IIBB-CSIC) and IIB Sant Pau, Hospital de Sant Pau, Barcelona 08025, Spain.
  14. 14Division of Cardiology and Molecular Cardiology, IRCCS Maugeri Foundation-University of Pavia, 27100 Pavia, Italy.
  15. 15Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.
  16. 16Department of Physiology and Biophysics, Rush University Medical Center, Chicago, IL 60612, USA.
  17. 17Child and Family Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada.
  18. 18Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, ON N6A 5A5, Canada.
  19. 19Molecular Cardiology Laboratory, Centro de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain.
  1. Corresponding author. Email: swchen{at} (S.R.W.C.); hkjensen{at} (H.K.J.); silvia.priori{at} (S.G.P.); jason.roberts{at} (J.D.R.); a.a.wilde{at} (A.A.M.W.); ssanatani{at} (S.S.)
  • * These authors contributed equally to this work.


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