Research ArticleCORONAVIRUS
Stereotypic neutralizing VH antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individuals
- View ORCID ProfileSang Il Kim1,2,*,
- View ORCID ProfileJinsung Noh3,*,
- View ORCID ProfileSujeong Kim1,4,
- View ORCID ProfileYounggeun Choi1,
- View ORCID ProfileDuck Kyun Yoo1,2,4,
- View ORCID ProfileYonghee Lee3,
- View ORCID ProfileHyunho Lee3,
- Jongtak Jung5,
- Chang Kyung Kang5,
- View ORCID ProfileKyoung-Ho Song5,
- View ORCID ProfilePyoeng Gyun Choe5,
- View ORCID ProfileHong Bin Kim5,
- View ORCID ProfileEu Suk Kim5,
- View ORCID ProfileNam-Joong Kim5,
- Moon-Woo Seong6,
- View ORCID ProfileWan Beom Park5,
- View ORCID ProfileMyoung-don Oh5,
- View ORCID ProfileSunghoon Kwon3,7,8,9,10,† and
- View ORCID ProfileJunho Chung1,4,11,†
- 1Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
- 2Ischemic/Hypoxic Disease Institute, Seoul National University Medical Research Center, Seoul 03080, Republic of Korea.
- 3Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, Republic of Korea.
- 4Department of Biomedical Science, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
- 5Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
- 6Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
- 7Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Republic of Korea.
- 8BK21+ Creative Research Engineer Development for IT, Seoul National University, Seoul 08826, Republic of Korea.
- 9Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Republic of Korea.
- 10Institutes of Entrepreneurial BioConvergence, Seoul National University, Seoul 08826, Republic of Korea.
- 11Cancer Research Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
- ↵†Corresponding author. Email: skwon{at}snu.ac.kr (S. Kwon); jjhchung{at}snu.ac.kr (J.C.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 27 Jan 2021:
Vol. 13, Issue 578, eabd6990
DOI: 10.1126/scitranslmed.abd6990
Vol. 13, Issue 578, eabd6990
DOI: 10.1126/scitranslmed.abd6990
Sang Il Kim
1Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
2Ischemic/Hypoxic Disease Institute, Seoul National University Medical Research Center, Seoul 03080, Republic of Korea.
Jinsung Noh
3Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, Republic of Korea.
Sujeong Kim
1Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
4Department of Biomedical Science, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Younggeun Choi
1Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Duck Kyun Yoo
1Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
2Ischemic/Hypoxic Disease Institute, Seoul National University Medical Research Center, Seoul 03080, Republic of Korea.
4Department of Biomedical Science, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Yonghee Lee
3Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, Republic of Korea.
Hyunho Lee
3Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, Republic of Korea.
Jongtak Jung
5Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Chang Kyung Kang
5Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Kyoung-Ho Song
5Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Pyoeng Gyun Choe
5Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Hong Bin Kim
5Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Eu Suk Kim
5Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Nam-Joong Kim
5Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Moon-Woo Seong
6Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Wan Beom Park
5Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Myoung-don Oh
5Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Sunghoon Kwon
3Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, Republic of Korea.
7Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Republic of Korea.
8BK21+ Creative Research Engineer Development for IT, Seoul National University, Seoul 08826, Republic of Korea.
9Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Republic of Korea.
10Institutes of Entrepreneurial BioConvergence, Seoul National University, Seoul 08826, Republic of Korea.
Junho Chung
1Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
4Department of Biomedical Science, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
11Cancer Research Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
