Research ArticleStem Cells

Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration

See allHide authors and affiliations

Science Translational Medicine  27 Jan 2021:
Vol. 13, Issue 578, eaaz8697
DOI: 10.1126/scitranslmed.aaz8697

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Decelerating degeneration

Mesenchymal stem cells (MSCs) have been used for tissue repair and regeneration, but the regenerative potential of the cells declines with aging. Lei et al. found that extracellular vesicles (EVs) from neonatal human umbilical cord MSCs (UC-EVs) could rejuvenate senescent adult MSCs derived from bone marrow. In mouse models, UC-EVs improved skin wound repair, decreased oxidative stress, and reduced aging-related markers in different organs. The authors identified the transfer of PCNA from UC-EVs to MSCs as a potential mechanism responsible for the rejuvenation. Results illustrate how treatment with UC-EVs could help combat aging-related degeneration.

View Full Text

Stay Connected to Science Translational Medicine