27 January 2021
Vol 13, Issue 578

About The Cover

Cover image expansion

ONLINE COVER In Situ SARS-CoV-2. The image shows severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA (red) within pneumocytes (blue) in a lung section from an African green monkey three days post virus inoculation. Speranza et al. characterized the dynamics of SARS-CoV-2 infection and the host immune response in African green monkeys. The authors used single cell RNA sequencing to compare immune cell populations in the lung and lymph nodes 3 and 10 days after inoculation, revealing a highly dynamic immune response in both tissues. These findings establish African green monkeys as an animal model of SARS-CoV-2 infection and may provide new insights into immune cell dynamics in humans infected with SARS-CoV-2. [CREDIT: SPERANZA ET AL./SCIENCE TRANSLATIONAL MEDICINE]