Contents
20 January 2021
Vol 13, Issue 577
Vol 13, Issue 577
Research Articles
- IgA dominates the early neutralizing antibody response to SARS-CoV-2
Early specific antibody responses against SARS-CoV-2 include IgG, IgM, and IgA, but IgA may neutralize virus and control infection to a larger extent.
- Enhanced SARS-CoV-2 neutralization by dimeric IgA
Human dimeric IgA antibodies are potent neutralizers of SARS-CoV-2.
- Characterization of ascites- and tumor-infiltrating γδ T cells reveals distinct repertoires and a beneficial role in ovarian cancer
γδ T cells are clonotypically distinct in ascites and tumors of patients with ovarian cancer and their functionality correlates with clinical outcome.
- The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography
An automated method to quantify TAU PET detected initial cortical tauopathy in Alzheimer’s disease and tracked subsequent amyloid-related TAU spread.
- Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma
The CHK1/2 inhibitor LY2606368 (prexasertib) sensitizes high-risk medulloblastoma to chemotherapy and improves survival in multiple in vivo models.
- ACE2 abrogates tumor resistance to VEGFR inhibitors suggesting angiotensin-(1-7) as a therapy for clear cell renal cell carcinoma
ACE2 is protective against renal cancer, and its down-modulation by inhibitors of VEGF receptor signaling may mediate resistance to such inhibitors.
- Diet-induced obesity promotes infection by impairment of the innate antimicrobial defense function of dermal adipocyte progenitors
Mature adipocytes that accumulate during obesity inhibit host defense against infection by feedback suppression of dermal adipocyte progenitors.
Perspective
- Does protein aggregation drive postmitotic tissue degeneration?
Pharmacological evidence from clinical trials demonstrates that protein aggregation drives tissue degeneration in systemic amyloid diseases.
Editors' Choice
- Could COVID-19 eliminate the alarm clock?
Social restriction due to COVID-19 relieves social jet lag.
- The benefits of memory growing granular
Brain imaging approaches show that the essential machinery for memory formation continues to develop into late childhood.
- Unconventional interleukin-1β release suppresses antitumor immunity
Inflammasome-independent release of IL-1β in the tumor microenvironment recruits T cell–suppressive neutrophils that support cancer progression.
About The Cover
ONLINE COVER Combating COVID-19. These computerized tomography scans of the chest from a patient with COVID-19 reveal ground glass opacities (blue) and lung consolidations (gray) dispersed throughout healthy tissue (yellow). Sterlin et al. characterized early antibody responses in the serum, saliva, and bronchoalveolar lavage fluid of 159 patients with COVID-19. The authors found that immunoglobulinA antibodies dominated the early immune response, whereas IgG antibodies were more common at later time points after symptom onset. Further, IgA antibodies isolated from the saliva and bronchioalveolar lavage fluid efficiently neutralized severe acute respiratory syndrome coronavirus 2. These findings suggest that vaccines which induce SARS-CoV-2–specific IgA antibody responses could provide protection in the lungs and respiratory tract. [CREDIT: P. QUENTRIC, A. MATHIAN, AND G. GOROCHOV/AP-HP SORBONNE UNIVERSITÉ]
