Enhanced SARS-CoV-2 neutralization by dimeric IgA

Zijun Wang; Julio C. C. Lorenzi; Frauke Muecksch; Shlomo Finkin; Charlotte Viant; Christian Gaebler; Melissa Cipolla; Hans-Heinrich Hoffmann; Thiago Y. Oliveira; Deena A. Oren; Victor Ramos; Lilian Nogueira; Eleftherios Michailidis; Davide F. Robbiani; Anna Gazumyan; Charles M. Rice; Theodora Hatziioannou; Paul D. Bieniasz; Marina Caskey; Michel C. Nussenzweig

doi:10.1126/scitranslmed.abf1555

Research ArticleCORONAVIRUS

Enhanced SARS-CoV-2 neutralization by dimeric IgA

View ORCID ProfileZijun Wang¹,*,
View ORCID ProfileJulio C. C. Lorenzi¹,*,
View ORCID ProfileFrauke Muecksch²,*,
View ORCID ProfileShlomo Finkin¹,*,
Charlotte Viant¹,
View ORCID ProfileChristian Gaebler ¹,
View ORCID ProfileMelissa Cipolla¹,
View ORCID ProfileHans-Heinrich Hoffmann³,
View ORCID ProfileThiago Y. Oliveira¹,
View ORCID ProfileDeena A. Oren⁴,
View ORCID ProfileVictor Ramos¹,
View ORCID ProfileLilian Nogueira¹,
View ORCID ProfileEleftherios Michailidis³,
View ORCID ProfileDavide F. Robbiani ⁵,
View ORCID ProfileAnna Gazumyan¹,
Charles M. Rice ³,
Theodora Hatziioannou²,
Paul D. Bieniasz ²,⁶,
View ORCID ProfileMarina Caskey¹ and
View ORCID ProfileMichel C. Nussenzweig ¹,⁶,†

¹Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
²Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA.
³Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
⁴Structural Biology Resource Center, The Rockefeller University, New York, NY 10065, USA.
⁵Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
⁶Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.

↵†Corresponding author. Email: nussen{at}rockefeller.edu

↵* These authors contributed equally to this work.

See allHide authors and affiliations

Science Translational Medicine 20 Jan 2021:
Vol. 13, Issue 577, eabf1555
DOI: 10.1126/scitranslmed.abf1555

Zijun Wang

1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Zijun Wang

Julio C. C. Lorenzi

1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Julio C. C. Lorenzi

Frauke Muecksch

2Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Frauke Muecksch

Shlomo Finkin

1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Shlomo Finkin

Charlotte Viant

1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Christian Gaebler

1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Christian Gaebler

Melissa Cipolla

1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Melissa Cipolla

Hans-Heinrich Hoffmann

3Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Hans-Heinrich Hoffmann

Thiago Y. Oliveira

1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Thiago Y. Oliveira

Deena A. Oren

4Structural Biology Resource Center, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Deena A. Oren

Victor Ramos

1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Victor Ramos

Lilian Nogueira

1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Lilian Nogueira

Eleftherios Michailidis

3Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Eleftherios Michailidis

Davide F. Robbiani

5Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Davide F. Robbiani

Anna Gazumyan

1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Anna Gazumyan

Charles M. Rice

3Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Theodora Hatziioannou

2Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Paul D. Bieniasz

2Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA.

6Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Marina Caskey

1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Marina Caskey

Michel C. Nussenzweig

1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

6Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Michel C. Nussenzweig
For correspondence: nussen@rockefeller.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Enhanced SARS-CoV-2 neutralization by dimeric IgA

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools