Research ArticleAlzheimer’s Disease

The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography

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Science Translational Medicine  20 Jan 2021:
Vol. 13, Issue 577, eabc0655
DOI: 10.1126/scitranslmed.abc0655

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Targeting TAU where it originates

Positron emission tomography (PET) has been shown to be effective in detecting TAU depositions in the brain of patients with Alzheimer’s disease (AD). Now, Sanchez et al. applied an automated method to quantify TAU progression in patients with AD at different stages. The authors found that TAU signal emerges first in the rhinal cortex independently of Aβ. Subsequent TAU elevation in the temporal neocortex was associated with age, Aβ, and APOE status. Longitudinal data in a subgroup of patients confirmed the TAU trajectory and showed that baseline TAU was associated with subsequent TAU spread. Targeting TAU in the temporal lobe might slow TAU spread and disease progression in patients with AD.

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