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An ACE2 in the hole
Clear cell renal cell carcinoma (ccRCC) is a form of kidney cancer commonly treated with agents targeting vascular endothelial growth factor (VEGF) signaling; however, resistance develops. Cotreatment with inhibitors of angiotensin signaling can improve survival, so Khanna et al. focused on the role of angiotensin converting enzyme 2 (ACE2), a natural antagonist of classical angiotensin signaling. Higher expression of ACE2 correlated with better survival in patients with ccRCC, and overexpression of ACE2 inhibited tumor colony formation. Combining angiotensin-(1-7), a cleavage product of ACE2, with VEGF inhibition provided greater antitumor effects than VEGF inhibition alone, suggesting a potential therapy for ccRCC.
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