Research ArticleCancer

Characterization of ascites- and tumor-infiltrating γδ T cells reveals distinct repertoires and a beneficial role in ovarian cancer

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Science Translational Medicine  20 Jan 2021:
Vol. 13, Issue 577, eabb0192
DOI: 10.1126/scitranslmed.abb0192

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An innate response to ovarian cancer

Favorable outcomes for patients with epithelial ovarian cancer have been associated with infiltration of immune cells into tumors. In this study, Foord et al. investigated the contribution of a subset of immune cells, γδ T cells, to clinical outcomes in these patients. The authors demonstrated that tumor-infiltrating γδ T cells isolated from patients with ovarian cancer have distinct T cell receptors and exhibit more innate-like functions compared to blood- or ascites-derived γδ T cells. Furthermore, γδ T cell infiltration into tumors was associated with increased survival in patients with ovarian cancer. These findings suggest that promoting γδ T cell responses may be a therapeutic option for ovarian cancer.

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