PerspectiveAMYLOID DISEASES

Does protein aggregation drive postmitotic tissue degeneration?

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Science Translational Medicine  20 Jan 2021:
Vol. 13, Issue 577, eaax0914
DOI: 10.1126/scitranslmed.aax0914

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Abstract

Pharmacological evidence, from clinical trials where patients with systemic amyloid diseases are treated with disease-modifying therapies, supports the notion that protein aggregation drives tissue degeneration in these disorders. The protein aggregate structures driving tissue pathology and the commonalities in etiology between these diseases and Alzheimer’s disease are under investigation.

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