20 January 2021
Vol 13, Issue 577

About The Cover

Cover image expansion

ONLINE COVER Combating COVID-19. These computerized tomography scans of the chest from a patient with COVID-19 reveal ground glass opacities (blue) and lung consolidations (gray) dispersed throughout healthy tissue (yellow). Sterlin et al. characterized early antibody responses in the serum, saliva, and bronchoalveolar lavage fluid of 159 patients with COVID-19. The authors found that immunoglobulinA antibodies dominated the early immune response, whereas IgG antibodies were more common at later time points after symptom onset. Further, IgA antibodies isolated from the saliva and bronchioalveolar lavage fluid efficiently neutralized severe acute respiratory syndrome coronavirus 2. These findings suggest that vaccines which induce SARS-CoV-2–specific IgA antibody responses could provide protection in the lungs and respiratory tract. [CREDIT: P. QUENTRIC, A. MATHIAN, AND G. GOROCHOV/AP-HP SORBONNE UNIVERSITÉ]