Contents
13 January 2021
Vol 13, Issue 576
Vol 13, Issue 576
Review
- The microbiota in pneumonia: From protection to predisposition
A healthy microbiota protects against pneumonia, and factors that alter the microbiota can predispose to pneumonia.
Research Articles
- Measurement of leukocyte trafficking kinetics in macaques by serial intravascular staining
Serial intravascular staining enables analysis of leukocyte migration in healthy nonhuman primates and those infected with Mycobacterium tuberculosis.
- Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease
Flow cytometric and transcriptomic analyses reveal coordinated tissue infiltration and tissue residence of donor T cells that drive gastrointestinal GVHD.
- Targeting cartilage EGFR pathway for osteoarthritis treatment
EGFR activation by overexpressing HBEGF in cartilage or intra-articular delivery of TGFα nanoparticles attenuates osteoarthritis development in mice.
- Kidney disease genetic risk variants alter lysosomal beta-mannosidase (MANBA) expression and disease severity
MANBA is a kidney disease risk gene that alters tubular endolysosomal function, inducing inflammasome activation and fibrosis.
- Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption
Interferon-mediated pressures vary throughout HIV-1 infection but are the highest during viral rebound after treatment interruption.
- The intratumoral CXCR3 chemokine system is predictive of chemotherapy response in human bladder cancer
Activity of the CXCR3alt-CXCL11 chemokine system in CD8+ stem-like T cells predicts chemotherapy response in patients with bladder cancer.
- Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth
Vaginally delivered nanoformulations of progesterone and histone deacetylase inhibitors prevent inflammation-induced preterm birth in mice.
Editors' Choice
- In aged hosts, T cells turn traitorous
Multimodal profiling of the aging immune system has identified highly abundant age–associated CD8+ T cells that home to organs and drive inflammation.
- A QuICR test to diagnose Parkinson’s disease
Refined conditions permit rapid detection of proteopathic α-synuclein seeds in cerebrospinal fluid from patients with Parkinson’s disease.
- Probing the entire vascular system
Microscopic endovascular probes that navigate by blood flow and an external magnetic field may increase the capabilities of vascular catheterization.
About The Cover
ONLINE COVER Leukocytes on the Run. This image shows the migration of blood leukocytes into a rhesus macaque lymph node. Using a technique termed serial intravascular staining (SIVS), Potter et al. intravenously administered anti-CD45 antibody to label blood leukocytes at 6 hours, 2 hours, and 5 minutes before necropsy, represented by red, teal, and green fluorescence, respectively. This serial staining produced a picture of migration into the lymph node over time. In a paired study by Tkachev et al., SIVS was used in combination with single cell RNA sequencing to characterize the role of donor CD8+ T cells in graft-versus-host disease in macaques. Thus, SIVS promises to improve our understanding of the dynamics of leukocyte trafficking in vivo. [CREDIT: E. LAKE POTTER AND GUILIA FABOZZI]
