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Research ArticleHIV
Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption
- View ORCID ProfileMarcos V. P. Gondim1,*,†,
- View ORCID ProfileScott Sherrill-Mix1,2,*,
- Frederic Bibollet-Ruche1,2,
- View ORCID ProfileRonnie M. Russell1,2,
- Stephanie Trimboli3,
- Andrew G. Smith4,
- Yingying Li1,
- Weimin Liu1,
- View ORCID ProfileAlexa N. Avitto5,
- Julia C. DeVoto6,
- View ORCID ProfileJesse Connell1,2,
- View ORCID ProfileAngharad E. Fenton-May7,
- Pierre Pellegrino8,
- View ORCID ProfileIan Williams8,
- Emmanouil Papasavvas9,
- View ORCID ProfileJulio C. C. Lorenzi10,
- View ORCID ProfileD. Brenda Salantes11,
- Felicity Mampe1,
- M. Alexandra Monroy1,
- View ORCID ProfileYehuda Z. Cohen12,
- View ORCID ProfileSonya Heath13,
- View ORCID ProfileMichael S. Saag13,
- View ORCID ProfileLuis J. Montaner9,
- View ORCID ProfileRonald G. Collman1,2,
- View ORCID ProfileJanet M. Siliciano14,
- View ORCID ProfileRobert F. Siliciano14,15,
- Lindsey J. Plenderleith16,17,
- Paul M. Sharp16,17,
- View ORCID ProfileMarina Caskey10,
- View ORCID ProfileMichel C. Nussenzweig10,18,
- View ORCID ProfileGeorge M. Shaw1,2,
- View ORCID ProfilePersephone Borrow7,
- View ORCID ProfileKatharine J. Bar1,2 and
- View ORCID ProfileBeatrice H. Hahn1,2,‡
- 1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 2Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 3University of Massachusetts Medical School, Worcester, MA 01655, USA.
- 4WuXi AppTec Inc., Philadelphia, PA 19112, USA.
- 5Gene Therapy Program, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 6Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
- 7Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK.
- 8Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London WC1E 6JB, UK.
- 9Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA 19104, USA.
- 10Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA.
- 11Century Therapeutics, Philadelphia, PA 19104, USA.
- 12Sanofi, Bridgewater, NJ 08807, USA.
- 13Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- 14Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
- 15Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD 21205, USA.
- 16Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK.
- 17Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3FL, UK.
- 18Howard Hughes Medical Institute, Rockefeller University, New York, NY 10065, USA.
- ↵‡Corresponding author. Email: bhahn{at}pennmedicine.upenn.edu
See allHide authors and affiliations
Science Translational Medicine 13 Jan 2021:
Vol. 13, Issue 576, eabd8179
DOI: 10.1126/scitranslmed.abd8179
Vol. 13, Issue 576, eabd8179
DOI: 10.1126/scitranslmed.abd8179
Marcos V. P. Gondim
1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Scott Sherrill-Mix
1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Frederic Bibollet-Ruche
1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ronnie M. Russell
1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Stephanie Trimboli
3University of Massachusetts Medical School, Worcester, MA 01655, USA.
Andrew G. Smith
4WuXi AppTec Inc., Philadelphia, PA 19112, USA.
Yingying Li
1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Weimin Liu
1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alexa N. Avitto
5Gene Therapy Program, University of Pennsylvania, Philadelphia, PA 19104, USA.
Julia C. DeVoto
6Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Jesse Connell
1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Angharad E. Fenton-May
7Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Pierre Pellegrino
8Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London WC1E 6JB, UK.
Ian Williams
8Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London WC1E 6JB, UK.
Emmanouil Papasavvas
9Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA 19104, USA.
Julio C. C. Lorenzi
10Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA.
D. Brenda Salantes
11Century Therapeutics, Philadelphia, PA 19104, USA.
Felicity Mampe
1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
M. Alexandra Monroy
1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yehuda Z. Cohen
12Sanofi, Bridgewater, NJ 08807, USA.
Sonya Heath
13Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Michael S. Saag
13Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Luis J. Montaner
9Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA 19104, USA.
Ronald G. Collman
1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Janet M. Siliciano
14Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Robert F. Siliciano
14Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
15Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD 21205, USA.
Lindsey J. Plenderleith
16Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK.
17Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3FL, UK.
Paul M. Sharp
16Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK.
17Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3FL, UK.
Marina Caskey
10Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA.
Michel C. Nussenzweig
10Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA.
18Howard Hughes Medical Institute, Rockefeller University, New York, NY 10065, USA.
George M. Shaw
1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Persephone Borrow
7Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Katharine J. Bar
1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Beatrice H. Hahn
1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
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