Research ArticleHIV

Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption

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Science Translational Medicine  13 Jan 2021:
Vol. 13, Issue 576, eabd8179
DOI: 10.1126/scitranslmed.abd8179

Article Information

vol. 13 no. 576

PubMed: 
Print ISSN: 
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History: 
  • Received for publication July 22, 2020
  • Resubmitted October 4, 2020
  • Accepted for publication November 30, 2020
  • .

Author Information

  1. Marcos V. P. Gondim1,*,,
  2. Scott Sherrill-Mix1,2,*,
  3. Frederic Bibollet-Ruche1,2,
  4. Ronnie M. Russell1,2,
  5. Stephanie Trimboli3,
  6. Andrew G. Smith4,
  7. Yingying Li1,
  8. Weimin Liu1,
  9. Alexa N. Avitto5,
  10. Julia C. DeVoto6,
  11. Jesse Connell1,2,
  12. Angharad E. Fenton-May7,
  13. Pierre Pellegrino8,
  14. Ian Williams8,
  15. Emmanouil Papasavvas9,
  16. Julio C. C. Lorenzi10,
  17. D. Brenda Salantes11,
  18. Felicity Mampe1,
  19. M. Alexandra Monroy1,
  20. Yehuda Z. Cohen12,
  21. Sonya Heath13,
  22. Michael S. Saag13,
  23. Luis J. Montaner9,
  24. Ronald G. Collman1,2,
  25. Janet M. Siliciano14,
  26. Robert F. Siliciano14,15,
  27. Lindsey J. Plenderleith16,17,
  28. Paul M. Sharp16,17,
  29. Marina Caskey10,
  30. Michel C. Nussenzweig10,18,
  31. George M. Shaw1,2,
  32. Persephone Borrow7,
  33. Katharine J. Bar1,2 and
  34. Beatrice H. Hahn1,2,
  1. 1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  2. 2Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  3. 3University of Massachusetts Medical School, Worcester, MA 01655, USA.
  4. 4WuXi AppTec Inc., Philadelphia, PA 19112, USA.
  5. 5Gene Therapy Program, University of Pennsylvania, Philadelphia, PA 19104, USA.
  6. 6Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  7. 7Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK.
  8. 8Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London WC1E 6JB, UK.
  9. 9Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA 19104, USA.
  10. 10Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA.
  11. 11Century Therapeutics, Philadelphia, PA 19104, USA.
  12. 12Sanofi, Bridgewater, NJ 08807, USA.
  13. 13Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  14. 14Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
  15. 15Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD 21205, USA.
  16. 16Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK.
  17. 17Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3FL, UK.
  18. 18Howard Hughes Medical Institute, Rockefeller University, New York, NY 10065, USA.
  1. Corresponding author. Email: bhahn{at}pennmedicine.upenn.edu
  • * These authors contributed equally to this work.

  • Present address: Bristol Myers Squibb, 556 Morris Avenue, Summit, NJ 07901, USA.

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