Research ArticleGRAFT VERSUS HOST DISEASE

Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease

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Science Translational Medicine  13 Jan 2021:
Vol. 13, Issue 576, eabc0227
DOI: 10.1126/scitranslmed.abc0227

Article Information

vol. 13 no. 576

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication April 8, 2020
  • Accepted for publication December 11, 2020
  • .

Author Information

  1. Victor Tkachev1,*,
  2. James Kaminski1,2,,
  3. E. Lake Potter3,,
  4. Scott N. Furlan4,,
  5. Alison Yu1,
  6. Daniel J. Hunt1,
  7. Connor McGuckin1,
  8. Hengqi Zheng5,
  9. Lucrezia Colonna4,,
  10. Ulrike Gerdemann1,
  11. Judith Carlson5,§,
  12. Michelle Hoffman4,
  13. Joe Olvera1,
  14. Chris English6,
  15. Audrey Baldessari6,
  16. Angela Panoskaltsis-Mortari7,
  17. Benjamin Watkins8,
  18. Muna Qayed8,
  19. Yvonne Suessmuth8,
  20. Kayla Betz1,
  21. Brandi Bratrude1,
  22. Amelia Langston8,
  23. John T. Horan8,
  24. Jose Ordovas-Montanes2,9,10,
  25. Alex K. Shalek2,11,12,
  26. Bruce R. Blazar7,
  27. Mario Roederer3 and
  28. Leslie S. Kean1,*
  1. 1Division of Pediatric Hematology/Oncology, Boston Children’s Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  2. 2Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  3. 3Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20858, USA.
  4. 4Fred Hutchinson Cancer Research Center, Department of Pediatrics, University of Washington, Seattle, WA 98109, USA.
  5. 5University of Washington, Seattle, WA 98195, USA.
  6. 6Washington National Primate Research Center, Seattle, WA 98195, USA.
  7. 7Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55454, USA.
  8. 8Emory University School of Medicine, Atlanta, GA 30322, USA.
  9. 9Division of Gastroenterology, Boston Children’s Hospital and Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.
  10. 10Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
  11. 11Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02142, USA.
  12. 12Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  1. *Corresponding author. Email: victor.tkachev{at}childrens.harvard.edu (V.T.); leslie.kean{at}childrens.harvard.edu (L.S.K.)
  • These authors contributed equally to this work.

  • Present address: Juno Therapeutics, Seattle, WA 98109, USA.

  • § Present address: St. Jude Research Hospital, Memphis, TN 38105, USA.

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